Xanthohumol, a Hop-derived Prenylated Flavonoid, Promotes Macrophage Reverse Cholesterol Transport

Xanthohumol, a prominent prenyl flavonoid from the hop plant (Humulus lupulus L.), is suggested to be anti-atherogenic since it reportedly increases HDL-cholesterol levels. It is not clear whether xanthohumol promotes reverse cholesterol transport (RCT), the most important anti-atherogenic property of HDL therefore we investigated the effects of xanthohumol on macrophage-to-feces RCT using a hamster model as a CETP-expressing species. In vivo RCT experiments showed xanthohumol significantly increased fecal appearance of the tracer derived from intraperitoneally injected [3H]-cholesterol-labeled macrophages.

Source: The Journal of Nutritional Biochemistry - April 22, 2017 Category: Biochemistry Authors: Hiroshi Hirata, Harumi Uto-Kondo, Masatsune Ogura, Makoto Ayaori, Kazusa Shiotani, Ami Ota, Youichi Tsuchiya, Katsunori Ikewaki Source Type: research