Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy

Sirtuin (SIRT1) inactivation underlies the pathogenesis of insulin resistance and hyperglycaemia associated vascular complications, but its role in diabetic neuropathy (DN) has not been yet explored. We have evaluated hyperglycaemia induced alteration of SIRT1 signalling and the effect of isoliquiritigenin (ILQ) on SIRT1 directed AMP kinase (AMPK) and peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC-1 α) signalling in peripheral nerves of streptozotocin (STZ) (55 mg/kg, i.p.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research