Addressing the inter ‐individual variation in response to consumption of plant food bioactives – towards a better understanding of their role in healthy ageing and cardiometabolic risk reduction
This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - September 29, 2016 Category: Nutrition Authors: Claudine Manach, Dragan Milenkovic, Tom de Wiele, Ana Rodriguez ‐Mateos, Baukje Roos, Maria Teresa Garcia‐Conesa, Rikard Landberg, Eileen R. Gibney, Marina Heinonen, Francisco Tomás‐Barberán, Christine Morand Tags: Review Source Type: research
Gut microbiota, diet, and obesity ‐related disorders—The good, the bad, and the future challenges
Diet has been shown to be a major factor in modulating the structure of the mammalian gut microbiota by providing specific nutrient sources and inducing environmental changes (pH, bile acids) in the gut ecosystem. Long‐term dietary patterns and short‐term interventions have been shown to induce changes in gut microbiota structure and function, with several studies revealing metabolic changes likely resulting from the host microbiota cross‐talk, which ultimately could influence host physiology. However, a more precise identification of the specific dietary patterns and food constituents that effectively modulate the g...
Source: Nahrung / Food - September 19, 2016 Category: Nutrition Authors: Kevin J. Portune, Alfonso Ben ítez‐Páez, Eva Maria Gomez Del Pulgar, Victor Cerrudo, Yolanda Sanz Tags: Review Source Type: research
Contents: Mol. Nutr. Food Res. 9'16
(Source: Nahrung / Food)
Source: Nahrung / Food - September 15, 2016 Category: Nutrition Tags: Contents Source Type: research
Editorial Board: Mol. Nutr. Food Res. 9'16
(Source: Nahrung / Food)
Source: Nahrung / Food - September 15, 2016 Category: Nutrition Tags: Editorial Board Source Type: research
Back cover: Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells
Mol. Nutr. Food Res. 2016, 60, 1924–1932.
DOI: 10.1002/mnfr.201500989
Dietary pterostilbene, a resveratrol derivative found in blueberries, is transformed to pinostilbene via demethylation in mice. The level of pinostilbene in the colonic mucosa of pterostilbene‐fed mice is relatively high, and at that level, pinostilbene inhibits human colon cancer cell growth by inducing cell cycle arrest and apoptosis. (Source: Nahrung / Food)
Source: Nahrung / Food - September 15, 2016 Category: Nutrition Authors: Yue Sun, Xian Wu, Xiaokun Cai, Mingyue Song, Jinkai Zheng, Che Pan, Peiju Qiu, Lijuan Zhang, Shuangde Zhou, Zhonghai Tang, Hang Xiao Tags: Back Cover Source Type: research
Inside front cover: Comparison of anti ‐inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis
Mol. Nutr. Food Res. 2016, 60, 1912–1923.
DOI: 10.1002/mnfr.201501008
Mango beverage (rich in gallotannins) inhibits the IGF‐1R‐AKT/mTOR axis, and pomegranate beverage (rich in ellagitannins) downregulates the mTOR downstream pathway through reduction of ERK1/2 in DSS‐treated rats. Gallic and ellagic acid are predicted in silico to bind to specific targets, such as IGF‐1R and EGFR. (Source: Nahrung / Food)
Source: Nahrung / Food - September 15, 2016 Category: Nutrition Authors: Hyemee Kim, Nivedita Banerjee, Ivan Ivanov, Catherine M. Pfent, Kalan R. Prudhomme, William H. Bisson, Roderick H. Dashwood, Stephen T. Talcott, Susanne U. Mertens ‐Talcott Tags: Inside front cover Source Type: research
Front cover: Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats
Mol. Nutr. Food Res. 2016, 60, 1902–1911.
DOI: 10.1002/mnfr.201500878
Carnosic acid (CA), which is extracted from Rosmarinus officinalis L, protects against chronic alcoholic liver injury by affecting lipid metabolism through the SIRT1‐ChREBP pathway and by regulating reactive oxygen species generation, inflammation, and apoptosis through the SIRT1‐p66shc pathway. (Source: Nahrung / Food)
Source: Nahrung / Food - September 15, 2016 Category: Nutrition Authors: Lili Gao, Wen Shan, Wenjing Zeng, Yan Hu, Guangzhi Wang, Xiaofeng Tian, Ning Zhang, Xue Shi, Yan Zhao, Chunchun Ding, Feng Zhang, Kexin Liu, Jihong Yao Tags: Front Cover Source Type: research
Safety aspects of the production of foods and food ingredients from insects
This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - September 13, 2016 Category: Nutrition Authors: Oliver Schl üter, Birgit Rumpold, Thomas Holzhauser, Angelika Roth, Rudi F. Vogel, Walter Quasigroch, Stephanie Vogel, Volker Heinz, Henry Jäger, Nils Bandick, Sabine Kulling, Dietrich Knorr, Pablo Steinberg, Karl‐Heinz Engel Tags: Review Source Type: research
A grape seed procyanidin extract inhibits HDAC activity leading to increased Ppar α phosphorylation and target gene expression
ConclusionGSPE regulates HDAC and Pparα activities to modulate lipid catabolism and reduce serum triglycerides in vivo.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - September 13, 2016 Category: Nutrition Authors: Laura E. Downing, Bradley S. Ferguson, Kelvin Rodriguez, Marie ‐Louise Ricketts Tags: Food & Function Source Type: research
A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome ‐mediated inflammation and improving insulin signaling
ConclusionThis novel CH partially protects mice against obesity‐induced hyperglycemia coincident with attenuated IL‐1β secretion and improved insulin signaling.
A hydrolysate derived from bovine milk casein (CH) reduces levels of the active form of the proinflammatory cytokine IL‐1β by impeding both signal 1 (pro‐IL‐1β transcription) and signal 2 (caspase‐1 activation) of the NLRP3 inflammasome. This anti‐inflammatory effect translates into improved glucose tolerance in vivo. (Source: Nahrung / Food)
Source: Nahrung / Food - September 7, 2016 Category: Nutrition Authors: Niamh P. Healy, Anna M. Kirwan, Maeve A. McArdle, Kieran Holohan, Alice B. Nongonierma, Deirdre Keane, Stacey Kelly, Lucia Celkova, Claire L. Lyons, Fiona C McGillicuddy, Orla M Finucane, Brian A. Murray, Philip M. Kelly, Lorraine Brennan, Richard J. Fitz Tags: Research Article Source Type: research
Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF ‐α stimulated proinflammatory environment
ConclusionThese results suggest that ACNs/PA‐RF may prevent atherogenesis while the effects of the single ACNs and metabolites are controversial and merit further exploration.
This study investigates the capacity of two different wild blueberry (Vaccinium angustifolium) fractions (anthocyanin‐rich‐ and phenolic‐acid‐rich fraction), single anthocyanins (malvidin, delphinidin, and cyanidin‐3‐glucoside) and metabolic products (syringic, gallic, and protocatechuic acid) to prevent monocytes adhesion to endothelial cells in a TNF‐α stimulated proinflammatory environment. The concentrations range from 0.01 μg/...
Source: Nahrung / Food - September 5, 2016 Category: Nutrition Authors: Cristian Del Bo', Martin Roursgaard, Marisa Porrini, Steffen Loft, Peter M øller, Patrizia Riso Tags: Research Article Source Type: research
The long chain α–tocopherol metabolite α‐13’‐COOH and γ‐tocotrienol induce P‐glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180
ConclusionBecause the induction of P‐gp in the intestine may limit the systemic bioavailability of its substrates, the concurrent intake of drugs and γ‐tocotrienol and, if ever applicable, α‐13’‐COOH should be avoided.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - August 31, 2016 Category: Nutrition Authors: Maren C. Podszun, Metta Jakobi, Marc Birringer, Johanna Weiss, Jan Frank Tags: Research Article Source Type: research
A serum metabolomics ‐driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study
Conclusions: We designed a new panel of biomarkers to differentiate the intake of OJs containing different doses of polyphenols. On the other hand, the consumption of an OJ with a high content of flavanones improved oxidative stress and inflammatory biomarkers.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - August 31, 2016 Category: Nutrition Authors: Oscar D Rangel ‐Huerta, Concepcion M Aguilera, Antonio Perez‐de‐la‐Cruz, Fernando Vallejo, Francisco Tomas‐Barberan, Angel Gil, Maria D Mesa Tags: Research Article Source Type: research
High phenolics Rutgers Scarlet Lettuce improves glucose metabolism in high fat diet ‐induced obese mice
ConclusionsRSL phenolics contributed to attenuation of post‐prandial hyperglycemia. Changes in gut microbiota were likely due to microbiota accessible carbohydrates in RSL and GL rather than RSL phenolics, which may be metabolized, absorbed, or degraded before reaching the colon.
Rutgers Scarlet Lettuce (RSL) phenolics, chlorogenic acid, quercetin malonyl‐glucoside, and cyanidin malonyl‐glucoside, contribute to attenuation of post‐prandial hyperglycemia. Changes in gut microbiota are due to the microbiota accessible carbohydrates in RSL and green lettuce diets rather than RSL phenolics, which are likely metabolize...
Source: Nahrung / Food - August 15, 2016 Category: Nutrition Authors: Diana M. Cheng, Diana E. Roopchand, Alexander Poulev, Peter Kuhn, Isabel Armas, William D. Johnson, Andrew Oren, David Ribnicky, Ehud Zelzion, Debashish Bhattacharya, Ilya Raskin Tags: Research Article Source Type: research
Effects of in vitro fermentation of barley β‐glucan and sugar beet pectin using human fecal inocula on cytokine expression by dendritic cells
ConclusionsThe fermentation of the two fibers led to fiber‐specific amounts of SCFA, glycosidic metabolites, and different immunomodulatory properties. BMDC from TLR2/4 knockout mice did not respond to the digest microbiota and SCFA, making it a useful approach to study temporal effects of fermentation on the immunomodulatory effects of fibers.
Dietary fibres influence the immune system. This stimulation by dietary fibres might be influenced by present endotoxins such as LPS. By using bone marrow derived dendritic cells (BMDCs) from TLR2/4 knockout mice, this undesired stimulation was circumvented and controls containin...
Source: Nahrung / Food - August 10, 2016 Category: Nutrition Authors: Christiane R ösch, Nico Taverne, Koen Venema, Harry Gruppen, Jerry M. Wells, Henk A. Schols Tags: Research Article Source Type: research
