The long chain α–tocopherol metabolite α‐13’‐COOH and γ‐tocotrienol induce P‐glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180

ConclusionBecause the induction of P‐gp in the intestine may limit the systemic bioavailability of its substrates, the concurrent intake of drugs and γ‐tocotrienol and, if ever applicable, α‐13’‐COOH should be avoided.This article is protected by copyright. All rights reserved

Source: Nahrung / Food - August 31, 2016 Category: Nutrition Authors: Maren C. Podszun, Metta Jakobi, Marc Birringer, Johanna Weiss, Jan Frank Tags: Research Article Source Type: research