Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor
Conclusion: RAME represses PDGF‐induced VSMC proliferation in vitro and reduces neointima formation in vivo. These results recommend RAME as an interesting compound with VSMC‐inhibiting potential. Future metabolism and pharmacokinetics studies might help to further evaluate the potential relevance of RAME and other spice‐derived polyphenolics for vasoprotection.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: Rongxia Liu, Elke H. Heiss, Birgit Waltenberger, Tina Bla žević, Daniel Schachner, Baohong Jiang, Vladimir Krystof, Wanhui Liu, Stefan Schwaiger, Luis M. Peña‐Rodríguez, Johannes M. Breuss, Hermann Stuppner, Verena M. Dirsch, Atanas G. Atanasov Tags: Research Article Source Type: research
Mice Fed a High ‐Cholesterol Diet Supplemented with Quercetin‐3‐Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas
Conclusion: In mice, dietary Q3G could counter HCD‐induced hyperlipidemia and hyperinsulinemia, in part by oppositely modulating hepatic and pancreatic PCSK9 secretion.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: Majambu Mbikay, Janice Mayne, Francine Sirois, Olesya Fedoryak, Angela Raymond, Jennifer Noad, Michel Chr étien Tags: RESEARCH ARTICLE Source Type: research
Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults
Conclusion: Plasma LA was inversely associated with adiposity, followed by haplotypes of FADS1/2 genes, carbohydrate intakes and dietary PUFA intakes. The association observed between plasma LA and adiposity may be linked to decreased de novo lipogenesis, insulin resistance and inflammation.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: Kaifeng Li, Lorraine Brennan, Jack F. Bloomfield, Dan J. Duff, Breige A. McNulty, Albert Flynn, JanetteMichael J. WaltonGibney, Anne P. Nugent Tags: Research Article Source Type: research
Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells
Conclusion: Taken together, these results indicate that Setd7 knockdown decreases Nrf2 and Nrf2‐target genes expression and that PEITC and UA induce Setd7 expression, which activates the Nrf2/antioxidant response element (ARE) signaling pathway and protects DNA from oxidative damage.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: Chao Wang, Limin Shu, Chengyue Zhang, Wenji Li, Renyi Wu, Yue Guo, Yuqing Yang, Ah ‐Ng Kong Tags: RESEARCH ARTICLE Source Type: research
A Phytol ‐Enriched Diet Activates PPARα in the Liver and Brown Adipose Tissue to Ameliorate Obesity‐Induced Metabolic Abnormalities
Conclusion: A phytol‐enriched diet may increase phytanic acid levels in the liver and brown adipocytes, thereby activating PPARα in these organs and ameliorating obesity‐induced metabolic diseases.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: Ji ‐Yeong An, Huei‐Fen Jheng, Hiroyuki Nagai, Kohei Sanada, Haruya Takahashi, Mari Iwase, Natsumi Watanabe, Young‐Il Kim, Aki Teraminami, Nobuyuki Takahashi, Rieko Nakata, Hiroyasu Inoue, Shigeto Seno, Hideo Mastuda, Teruo Kawada, Tsuyoshi Goto Tags: RESEARCH ARTICLE Source Type: research
Stachyose Improves Inflammation Through Modulating Gut Microbiota of High ‐Fat Diet / Streptozotocin Induced Type 2 Diabetes in Rats
ConclusionSTS decreased pancreatic mRNA expression of IL‐6 and TNF‐α via key species of gut microbiota. The mechanism of this effect was similar to that of MET.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: Guimei Liu, Jia Bei, Li Liang, Guoyong Yu, Lu Li, Quanhong Li Tags: Research Article Source Type: research
Human Intestinal Dendritic Cells in Inflammatory Bowel Diseases
This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: David Bernardo, Mar ía Chaparro, Javier P Gisbert Tags: Review Source Type: research
Raspberry Supplementation Improves Insulin Signaling and Promotes Brown ‐Like Adipocyte Development in White Adipose Tissue of Obese Mice
Conclusion: Dietary RB attenuated adipocyte hypertrophy and inflammation of WAT in HFD‐mice and improved insulin sensitivity and beige adipogenesis, which is associated with increased FNDC5/irisin content and activation of AMPK/Sirt1 pathway. RB supplementation provides a promising strategy to prevent diet‐induced obesity.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: Tong Xing, Yifei Kang, Xinglian Xu, Bo Wang, Min Du, Mei ‐Jun Zhu Tags: FOOD & FUNCTION Source Type: research
Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
ConclusionThese findings suggest that TQ has an enhancing effect on cell survival and neurogenesis in healthy hippocampus rather inducing apoptosis in damaged neurons. This may proceed via ERK/JNK and CREB signaling pathways as a candidate acting mechanism for TQ.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 26, 2017 Category: Nutrition Authors: Merve Beker, Tu ğçe Dallı, Birsen Elibol Tags: Research Article Source Type: research
Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle ‐Aged Rats by Suppressing the Glycosylation Process
ConclusionIntake of fish oil at a normal dose downregulated colonic Muc2 expression. This negative effect of fish oil may involve the suppression of mucin glycosylation process.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 26, 2017 Category: Nutrition Authors: Yafang Ma, Guanghong Zhou, Yingqiu Li, Yingying Zhu, Xiaobo Yu, Fan Zhao, He Li, Xinglian Xu, Chunbao Li Tags: Research Article Source Type: research
Bioavailability of Glucoraphanin and Sulforaphane From High ‐Glucoraphanin Broccoli
ConclusionThis is the first study to report the bioavailability of glucoraphanin and sulforaphane from soups made with novel broccoli varieties. The presence of one or two Myb28V alleles results in enhanced delivery of sulforaphane to the systemic circulation.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 21, 2017 Category: Nutrition Authors: Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W. Needs, Maria H. Traka, Henri Tapp, Jack R. Dainty, Richard F. Mithen Tags: Research Article Source Type: research
Vitamin A Deficiency Induces Autistic ‐Like Behaviors in Rats by Regulating the RARβ‐CD38‐Oxytocin Axis in the Hypothalamus
Conclusions: Gestational VAD might be a risk factor for autistic‐like behaviors due to the RARβ signal suppression of CD38 expression in the hypothalamus of the offspring, which improved with VAS during the early‐life period. The nutritional status during pregnancy and the early‐life period is important in rats.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 21, 2017 Category: Nutrition Authors: Xi Lai, Xiaofeng Wu, Nali Hou, Shu Liu, Qing Li, Ting Yang, Jingkun Miao, Zhifang Dong, Jie Chen, Tingyu Li Tags: Research Article Source Type: research
Mediterranean Tomato ‐Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats
Conclusions: A sofrito‐supplemented diet improves insulin and FGF21 sensitivity in OZR, explaining part of sofrito’s healthy effects on glucose metabolism. In addition, induction of UCP1 and the unchanged body weight despite the hyperphagic behavior of the sofrito‐fed rats suggests that the increase in FGF21 signaling correlates with an increase in energy expenditure (EE). Further studies in humans may help to understand whether sofrito consumption increases the EE in obese individuals.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 21, 2017 Category: Nutrition Authors: Viviana Sandoval, Rosal ía Rodríguez‐Rodríguez, Úrsula Martínez‐Garza, Cristina Rosell‐Cardona, Rosa Lamuela‐Raventós, Pedro F. Marrero, Diego Haro, Joana Relat Tags: Food & Function Source Type: research
Naringin Protects Pancreatic β‐Cells Against Oxidative Stress‐Induced Apoptosis by Inhibiting Both Intrinsic and Extrinsic Pathways in Insulin‐Deficient Diabetic Mice
Conclusion: Taken together, our study provides insights into the underlying mechanisms through which naringin protects the pancreatic β‐cells against oxidative stress‐induced apoptosis.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 1, 2017 Category: Nutrition Authors: Ye Jin Lim, Jung Ho Kim, Jeong Hoon Pan, Jae Kyeom Kim, Tae ‐Sik Park, Young Jun Kim, Jin Hyup Lee, Jun Ho Kim Tags: Research Article Source Type: research
Extracellular Vesicles from Hypoxic Adipocytes and obese subjects reduce Insulin ‐Stimulated Glucose Uptake
Conclusion: Extracellular vesicles released by stressed adipocytes impair insulin action in neighbouring adipocytes.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 1, 2017 Category: Nutrition Authors: Justyna Mleczko, Francisco J. Ortega, Juan Manuel Falcon ‐Perez, Martin Wabitsch, Jose Manuel Fernandez‐Real, Silvia Mora Tags: Food & Function Source Type: research
