Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells

Conclusion: Taken together, these results indicate that Setd7 knockdown decreases Nrf2 and Nrf2‐target genes expression and that PEITC and UA induce Setd7 expression, which activates the Nrf2/antioxidant response element (ARE) signaling pathway and protects DNA from oxidative damage.This article is protected by copyright. All rights reserved

Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: Chao Wang, Limin Shu, Chengyue Zhang, Wenji Li, Renyi Wu, Yue Guo, Yuqing Yang, Ah ‐Ng Kong Tags: RESEARCH ARTICLE Source Type: research