Distribution of trans ‐resveratrol and its metabolites after acute or sustained administration in mouse heart, brain, and liver
Conclusions: Our results show notable differences between acute and sustained administration of trans‐resveratrol and distribution of trans‐resveratrol and its metabolites in mouse heart, brain, and liver. The results suggest a strategy for development of galenic forms of resveratrol.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 31, 2017 Category: Nutrition Authors: Marie ‐Claude Menet, Stephanie Baron, Meryam Taghi, Remi Diestra, Delphine Dargère, Olivier Laprévote, Valérie Nivet‐Antoine, Jean‐Louis Beaudeux, Tatiana Bédarida, Charles‐Henry Cottart Tags: Research Article Source Type: research
Advanced glycation end products stimulate gene expression of fibroblast growth factor 23
ConclusionsSource of AGEs induce the transcription of Fgf23 in UMR cells. At least in part, the effect is mediated through up‐regulation of NFκB and subsequent SOCE. AGE‐induced FGF23 production may contribute to increased FGF23 serum levels observed in chronic disease.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 27, 2017 Category: Nutrition Authors: Ludmilla B är, Kristin Wächter, Nicole Wege, Alexander Navarrete Santos, Andreas Simm, Michael Föller Tags: Research Article Source Type: research
Mediterranean diet –gene interactions: A targeted metabolomics study in Greek‐Cypriot women
ConclusionSerum levels of flavin mononucleotide and 5‐MTHF were shown to be influenced by interactions between GSTM1 deletion or MTHFR (rs1801133) polymorphisms and a dietary pattern, characteristic of MD.
The effect of the interactions between polymorphisms and Mediterranean diet adherence on the levels of specific metabolites is studied. The levels of the metabolites are measured in the serum of 564 Greek‐Cypriot breast cancer controls. Significant interactions between GSTM1 (where GST is glutathione S‐transferase) deletion or MTHFR (rs1801133) polymorphisms and Mediterranean diet are shown to affect levels of fla...
Source: Nahrung / Food - January 24, 2017 Category: Nutrition Authors: Maria G. Kakkoura, Kleitos Sokratous, Christiana A. Demetriou, Maria A. Loizidou, Giorgos Loucaides, Eleni Kakouri, Andreas Hadjisavvas, Kyriacos Kyriacou Tags: Research Article Source Type: research
Availability and dose response of phytophenols from a wheat bran rich cereal product in healthy human volunteers
ConclusionAnalysis of the systemic metabolomes demonstrated that a wide range of phytophenols were absorbed/excreted (43 metabolites) within 5 h of consumption. These included 16 of the 21 major parent compounds identified in the intervention product and several of these were also found to be significantly increased in the colon. Not all of the metabolites were increased with the higher dose, suggesting some limitation in absorption due to intrinsic factors and/or the food matrix. Many compounds identified (e.g. ferulic acid and major metabolites) exhibit anti‐inflammatory activity and impact on redox pathways. The combi...
Source: Nahrung / Food - January 24, 2017 Category: Nutrition Authors: Madalina Neacsu, Jolene McMonagle, Reg J. Fletcher, Toine Hulshof, Sylvia H. Duncan, Lorraine Scobbie, Gary J. Duncan, Louise Cantlay, Graham Horgan, Baukje Roos, Garry G. Duthie, Wendy R. Russell Tags: Research Article Source Type: research
Defining genetic and chemical diversity in wheat grain by 1H ‐NMR spectroscopy of polar metabolites
Conclusionshigh throughput 1H‐NMR is an excellent tool to compare the extent of genetic diversity within and between wheat species, and to quantify specific components (including glycine betaine, choline and asparagine) in individual genotypes. It can also be used to monitor changes in composition related environmental factors and to support comparisons of the substantial equivalence of transgenic lines.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 12, 2017 Category: Nutrition Authors: Peter R. Shewry, Delia I. Corol, Huw D. Jones, Michael H. Beale, Jane L. Ward Tags: Research Article Source Type: research
Dietary total flavonoids intake and risk of mortality from all causes and cardiovascular disease in the general population: a systematic review and meta ‐analysis of cohort studies
ConclusionsThe meta‐analysis provides strong evidence for the recommendation of consuming flavonoids‐rich food to reduce risks of mortality from all causes as part of a healthy diet among general adults.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - January 4, 2017 Category: Nutrition Authors: Xue ‐ming Liu, Yu‐jian Liu, Yao Huang, Hong‐jie Yu, Shuai Yuan, Bo‐wen Tang, Pei‐gang Wang, Qi‐qiang He Tags: Review Source Type: research
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane ‐treated colon cancer cells
ConclusionNMRAL2P is the first functional pseudogene to be identified both as a direct transcriptional target of Nrf2, and as a downstream regulator of Nrf2‐dependent NQO1 induction. Further studies are warranted on NMRAL2P‐Nrf2 crosstalk and the associated mechanisms of gene regulation.
NmrA‐like redox sensor 2 (NMRAL2P) is a novel functional pseudogene, the first to be identified both as a direct transcriptional target of Nrf2, and as a downstream coregulator of Nrf2‐dependent gene activation in response to sulforaphane treatment. (Source: Nahrung / Food)
Source: Nahrung / Food - January 2, 2017 Category: Nutrition Authors: Gavin S. Johnson, Jia Li, Laura M. Beaver, W. Mohaiza Dashwood, Deqiang Sun, Praveen Rajendran, David E. Williams, Emily Ho, Roderick H. Dashwood Tags: Research Article Source Type: research
Variations in dietary intake and plasma concentration of plant sterols across plant ‐based diets among North American adults
Conclusion: Dietary intake but not plasma concentration of plant sterols and cholesterol varies across distinct plant‐based diets.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 31, 2016 Category: Nutrition Authors: Karen Jaceldo ‐Siegl, Dieter Lütjohann, Rawiwan Sirirat, Andrew Mashchak, Gary E. Fraser, Ella Haddad Tags: Research Article Source Type: research
Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro
ConclusionOur study demonstrates that chicory inulin, as a nutritional supplement, may be beneficial for the patients with type 2 diabetes mellitus, and the metabolism‐modulatory effect seems to be related to the inhibition of JNK and P38 MAPK pathways.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 31, 2016 Category: Nutrition Authors: Chong Ning, Xiyao Wang, Song Gao, Jingjing Mu, Yuehua Wang, Suwen Liu, Jinyan Zhu, Xianjun Meng Tags: Research Article Source Type: research
Increasing dietary nitrate has no effect on cancellous bone loss or fecal microbiome in ovariectomized rats
This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 31, 2016 Category: Nutrition Authors: Melissa N. Conley, Cooper Roberts, Thomas J. Sharpton, Urszula T. Iwaniec, Norman Hord Tags: Research Article Source Type: research
Neoagarotetraose protects mice against intense exercise induced fatigue damage by modulating gut microbial composition and function
ConclusionTogether, our findings suggest that NAT may protect mice against intense exercise‐induced fatigue and provide insights into the mechanisms of NAT as a potential prebiotic.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 31, 2016 Category: Nutrition Authors: Na Zhang, Xiangzhao Mao, Robert W. Li, Enling Hou, Yuming Wang, Changhu Xue, Qingjuan Tang Tags: Research Article Source Type: research
A low ‐protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic Fibroblast Growth Factor 21 (FGF21)
Conclusions: Our results reinforce the involvement of FGF21 in coordinating energy homeostasis under a range of nutritional conditions. Moreover, here we describe an approach to increase the endogenous production of FGF21, which if demonstrated functional in humans, could generate a treatment for obesity.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 31, 2016 Category: Nutrition Authors: Albert P érez‐Martí, Maite Garcia‐Guasch, Anna Tresserra‐Rimbau, Alexandra Carrilho‐Do‐Rosário, Ramon Estruch, Jordi Salas‐Salvadó, Miguel Ángel Martínez‐González, Rosa Lamuela‐Raventós, Pedro F. Marrero, Diego Haro, Joana Relat Tags: Research Article Source Type: research
Aged garlic extract suppresses the increase of plasma glycated albumin level and enhances the AMP ‐activated protein kinase in adipose tissue in TSOD mice
ConclusionAGE treatment suppresses the increase of plasma glycated albumin level in TSOD mice and this effect is accompanied by the activation of AMPK in adipose tissue, and suggests that AGE may play a potential role in the prevention and treatment of type 2 diabetes.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 31, 2016 Category: Nutrition Authors: Satomi Miki, Ken ‐ichi Inokuma, Miyuki Takashima, Mitsuho Nishida, Yoko Sasaki, Mitsuyasu Ushijima, Jun‐ichiro Suzuki, Naoaki Morihara Tags: Food & Function Source Type: research
Identification and implication of an allergenic PR ‐10 protein from walnut in birch pollen associated walnut allergy
Conclusion: A Bet v 1‐like allergen was identified in walnut. Diagnostic use of Jug r 5 will compensate for the low sensitivity of walnut extract for patients with birch pollen associated walnut allergy.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 31, 2016 Category: Nutrition Authors: Andrea Wangorsch, Annette Jamin, Jonas Lidholm, Nora Gr äni, Claudia Lang, Barbara Ballmer‐Weber, Stefan Vieths, Stephan Scheurer Tags: Research Article Source Type: research
Treatment with alpha ‐galactosylceramide protects mice from early onset of non‐alcoholic steatohepatitis: role of intestinal barrier function
ConclusionTaken together, our data suggest that the protective effects of αGalCer against the development of a diet‐induced NASH in mice are associated with a protection against the increased translocation of intestinal bacterial endotoxins associated with the development of NASH.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 31, 2016 Category: Nutrition Authors: Anna Janina Engstler, Cathrin Sellmann, Cheng Jun Jin, Annette Brandt, Kathleen Herz, Josephine Priebs, Ina Bergheim Tags: Research Article Source Type: research
