Availability and dose response of phytophenols from a wheat bran rich cereal product in healthy human volunteers

ConclusionAnalysis of the systemic metabolomes demonstrated that a wide range of phytophenols were absorbed/excreted (43 metabolites) within 5 h of consumption. These included 16 of the 21 major parent compounds identified in the intervention product and several of these were also found to be significantly increased in the colon. Not all of the metabolites were increased with the higher dose, suggesting some limitation in absorption due to intrinsic factors and/or the food matrix. Many compounds identified (e.g. ferulic acid and major metabolites) exhibit anti‐inflammatory activity and impact on redox pathways. The combination of postprandial absorption and delivery to the colon, as well as hepatic recycling of the metabolites at these concentrations, is likely to be beneficial to both systemic and gut health.

Consumption of wheat bran rich test meals deliver a wide range of phytophenol metabolites to the colon and systemic circulation (through postprandial absorption and hepatic recycling). Not all metabolites increase with the higher dose, suggesting limitation due to intrinsic factors and/or the food matrix. Many compounds identified by targeted LC‐MS exhibit anti‐inflammatory activity, as well as impacting on redox pathways and are likely to be beneficial to both systemic and gut health.

Source: Nahrung / Food - January 24, 2017 Category: Nutrition Authors: Madalina Neacsu, Jolene McMonagle, Reg J. Fletcher, Toine Hulshof, Sylvia H. Duncan, Lorraine Scobbie, Gary J. Duncan, Louise Cantlay, Graham Horgan, Baukje Roos, Garry G. Duthie, Wendy R. Russell Tags: Research Article Source Type: research