A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane ‐treated colon cancer cells

ConclusionNMRAL2P is the first functional pseudogene to be identified both as a direct transcriptional target of Nrf2, and as a downstream regulator of Nrf2‐dependent NQO1 induction. Further studies are warranted on NMRAL2P‐Nrf2 crosstalk and the associated mechanisms of gene regulation.

NmrA‐like redox sensor 2 (NMRAL2P) is a novel functional pseudogene, the first to be identified both as a direct transcriptional target of Nrf2, and as a downstream coregulator of Nrf2‐dependent gene activation in response to sulforaphane treatment.

Source: Nahrung / Food - January 2, 2017 Category: Nutrition Authors: Gavin S. Johnson, Jia Li, Laura M. Beaver, W. Mohaiza Dashwood, Deqiang Sun, Praveen Rajendran, David E. Williams, Emily Ho, Roderick H. Dashwood Tags: Research Article Source Type: research