Advanced glycation end products stimulate gene expression of fibroblast growth factor 23

ConclusionsSource of AGEs induce the transcription of Fgf23 in UMR cells. At least in part, the effect is mediated through up‐regulation of NFκB and subsequent SOCE. AGE‐induced FGF23 production may contribute to increased FGF23 serum levels observed in chronic disease.This article is protected by copyright. All rights reserved

Source: Nahrung / Food - January 27, 2017 Category: Nutrition Authors: Ludmilla B är, Kristin Wächter, Nicole Wege, Alexander Navarrete Santos, Andreas Simm, Michael Föller Tags: Research Article Source Type: research