Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

Conclusion: RAME represses PDGF‐induced VSMC proliferation in vitro and reduces neointima formation in vivo. These results recommend RAME as an interesting compound with VSMC‐inhibiting potential. Future metabolism and pharmacokinetics studies might help to further evaluate the potential relevance of RAME and other spice‐derived polyphenolics for vasoprotection.This article is protected by copyright. All rights reserved

Source: Nahrung / Food - January 1, 2018 Category: Nutrition Authors: Rongxia Liu, Elke H. Heiss, Birgit Waltenberger, Tina Bla žević, Daniel Schachner, Baohong Jiang, Vladimir Krystof, Wanhui Liu, Stefan Schwaiger, Luis M. Peña‐Rodríguez, Johannes M. Breuss, Hermann Stuppner, Verena M. Dirsch, Atanas G. Atanasov Tags: Research Article Source Type: research