A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome ‐mediated inflammation and improving insulin signaling

ConclusionThis novel CH partially protects mice against obesity‐induced hyperglycemia coincident with attenuated IL‐1β secretion and improved insulin signaling.

A hydrolysate derived from bovine milk casein (CH) reduces levels of the active form of the proinflammatory cytokine IL‐1β by impeding both signal 1 (pro‐IL‐1β transcription) and signal 2 (caspase‐1 activation) of the NLRP3 inflammasome. This anti‐inflammatory effect translates into improved glucose tolerance in vivo.

Source: Nahrung / Food - September 7, 2016 Category: Nutrition Authors: Niamh P. Healy, Anna M. Kirwan, Maeve A. McArdle, Kieran Holohan, Alice B. Nongonierma, Deirdre Keane, Stacey Kelly, Lucia Celkova, Claire L. Lyons, Fiona C McGillicuddy, Orla M Finucane, Brian A. Murray, Philip M. Kelly, Lorraine Brennan, Richard J. Fitz Tags: Research Article Source Type: research