Nature Reviews Molecular Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Epigenetic control of adult stem cell function
Nature Reviews Molecular Cell Biology 17, 643 (2016).
doi:10.1038/nrm.2016.76
Authors: Alexandra Avgustinova & Salvador Aznar Benitah
Mammalian embryonic development is a tightly regulated process that, from a single zygote, produces a large number of cell types with hugely divergent functions. Distinct cellular differentiation programmes are facilitated by tight transcriptional and epigenetic regulation. However, the contribution of epigenetic regulation to tissue homeostasis (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 12, 2016 Category: Cytology Authors: Alexandra Avgustinova Salvador Aznar Benitah Tags: Review Source Type: research
Applying CRISPR –Cas9 tools to identify and characterize transcriptional enhancers
Nature Reviews Molecular Cell Biology 17, 597 (2016).
doi:10.1038/nrm.2016.79
Authors: Rui Lopes, Gozde Korkmaz & Reuven Agami
The development of the CRISPR–Cas9 system triggered a revolution in the field of genome engineering. Initially, the use of this system was focused on the study of protein-coding genes but, recently, a number of CRISPR–Cas9-based tools have been developed to study non-coding transcriptional regulatory elements. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 5, 2016 Category: Cytology Authors: Rui Lopes Gozde Korkmaz Reuven Agami Tags: Perspectives Source Type: research
Mechanistic insights into selective autophagy pathways: lessons from yeast
Nature Reviews Molecular Cell Biology 17, 537 (2016).
doi:10.1038/nrm.2016.74
Authors: Jean-Claude Farré & Suresh Subramani
Autophagy has burgeoned rapidly as a field of study because of its evolutionary conservation, the diversity of intracellular cargoes degraded and recycled by this machinery, the mechanisms involved, as well as its physiological relevance to human health and disease. This self-eating process was initially viewed (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 5, 2016 Category: Cytology Authors: Jean-Claude Farr é Suresh Subramani Tags: Review Source Type: research
Protein translocation: Channelling the route for ER misfolded proteins
Nature Reviews Molecular Cell Biology 17, 462 (2016).
doi:10.1038/nrm.2016.92
Author: Paulina Strzyz
Hrd1 may form a channel regulated by autoubiquitylation that has a major role in translocating misfolded proteins from the ER lumen to the cytoplasm for subsequent degradation. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 5, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Cancer biology: The dark side of p21
Nature Reviews Molecular Cell Biology 17, 461 (2016).
doi:10.1038/nrm.2016.90
Author: Eytan Zlotorynski
Whereas activation of p21 by p53 causes G1 cell cycle arrest, p53-independent expression of p21 can cause deregulation of DNA replication and genomic instability. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 5, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Tight junctions: from simple barriers to multifunctional molecular gates
Nature Reviews Molecular Cell Biology 17, 564 (2016).
doi:10.1038/nrm.2016.80
Authors: Ceniz Zihni, Clare Mills, Karl Matter & Maria S. Balda
Epithelia and endothelia separate different tissue compartments and protect multicellular organisms from the outside world. This requires the formation of tight junctions, selective gates that control paracellular diffusion of ions and solutes. Tight junctions also form the border between the apical and basolateral plasma-membrane domains (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 28, 2016 Category: Cytology Authors: Ceniz Zihni Clare Mills Karl Matter Maria S. Balda Tags: Review Source Type: research
Coupling changes in cell shape to chromosome segregation
Nature Reviews Molecular Cell Biology 17, 511 (2016).
doi:10.1038/nrm.2016.75
Authors: Nitya Ramkumar & Buzz Baum
Animal cells undergo dramatic changes in shape, mechanics and polarity as they progress through the different stages of cell division. These changes begin at mitotic entry, with cell–substrate adhesion remodelling, assembly of a cortical actomyosin network and osmotic swelling, which together enable cells to adopt (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 28, 2016 Category: Cytology Authors: Nitya Ramkumar Buzz Baum Tags: Review Source Type: research
DNA replication and beyond
Nature Reviews Molecular Cell Biology 17, 464 (2016).
doi:10.1038/nrm.2016.89
Author: Joseph G. Gall
It turns out that Meselson and Stahl were not the first to show that DNA replicates semi-conservatively. The preceding experiment was almost forgotten, partly because it showed something incredible. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 28, 2016 Category: Cytology Authors: Joseph G. Gall Tags: Research Highlight Source Type: research
Stem cells: Engineering an artificial niche for cell quiescence
Nature Reviews Molecular Cell Biology 17, 398 (2016).
doi:10.1038/nrm.2016.82
Author: Kim Baumann
The engineering of an artificial niche for the maintenance of quiescent muscle stem cells in vitro is reported. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 21, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Post-translational modifications: ADP-ribosylation promotes transcription elongation
Nature Reviews Molecular Cell Biology 17, 397 (2016).
doi:10.1038/nrm.2016.83
Author: Eytan Zlotorynski
The use of a chemical genetics approach to identify poly(ADP-ribose) polymerase (PARP) targets revealed that PARP1 promotes transcription elongation. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 21, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
DNA damage response: Cell thriving despite DNA damage
Nature Reviews Molecular Cell Biology 17, 396 (2016).
doi:10.1038/nrm.2016.86
Author: Paulina Strzyz
DNA damage response (DDR) pathways prevent genomic instability by inducing cell-cycle arrest, DNA repair or apoptosis following DNA damage, and are known to be inactivated in polyploid cells as well as in many cancers. Bretscher and Fox used the developing fly papillar cells — a (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 21, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Autophagy: Shrinking through cilia-induced self-eating
Nature Reviews Molecular Cell Biology 17, 396 (2016).
doi:10.1038/nrm.2016.85
Author: Paulina Strzyz
Epithelial cells of the kidney proximal tubules, which reabsorb water and nutrients from the forming urine, shrink in response to fluid flow through mechanisms that involve mechanosensing by primary cilia. Orhon et al. demonstrated that the application of fluid flow induced autophagy in cultured (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 21, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Small RNAs: New microRNA-like molecules
Nature Reviews Molecular Cell Biology 17, 396 (2016).
doi:10.1038/nrm.2016.84
Author: Eytan Zlotorynski
Hansen et al. describe a new class of short regulatory RNAs, which associate with Argonaute (AGO) proteins and derive from short introns, hence are termed agotrons. The authors annotated 87 agotrons in human and 18 in mouse, and found that they are conserved across (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 21, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Regulating Rho GTPases and their regulators
Nature Reviews Molecular Cell Biology 17, 496 (2016).
doi:10.1038/nrm.2016.67
Authors: Richard G. Hodge & Anne J. Ridley
Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a wide range of cellular processes, including cell migration, cell polarity and cell cycle progression. Most Rho GTPases cycle between a GTP-bound active conformation and a GDP-bound inactive conformation to regulate their ability to (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 14, 2016 Category: Cytology Authors: Richard G. Hodge Anne J. Ridley Tags: Review Source Type: research
Chaperoning SNARE assembly and disassembly
Nature Reviews Molecular Cell Biology 17, 465 (2016).
doi:10.1038/nrm.2016.65
Authors: Richard W. Baker & Frederick M. Hughson
Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). However, the assembly of such complexes in vitro is inefficient, and their uncatalysed disassembly is undetectably slow. Here, we focus on the cellular machinery (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 14, 2016 Category: Cytology Authors: Richard W. Baker Frederick M. Hughson Tags: Review Source Type: research
