Nature Reviews Molecular Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Mechanobiology of YAP and TAZ in physiology and disease
Nature Reviews Molecular Cell Biology 18, 758 (2017).
doi:10.1038/nrm.2017.87
Authors: Tito Panciera, Luca Azzolin, Michelangelo Cordenonsi & Stefano Piccolo
A growing body of evidence suggests that mechanical signals emanating from the cell's microenvironment are fundamental regulators of cell behaviour. Moreover, at the macroscopic scale, the influence of forces, such as the forces generated by blood flow, muscle contraction, gravity and overall tissue rigidity (for (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 27, 2017 Category: Cytology Authors: Tito Panciera Luca Azzolin Michelangelo Cordenonsi Stefano Piccolo Tags: Review Source Type: research
Mechanistic insights into precursor messenger RNA splicing by the spliceosome
Nature Reviews Molecular Cell Biology 18, 655 (2017).
doi:10.1038/nrm.2017.86
Author: Yigong Shi
Precursor messenger RNA (pre-mRNA) splicing is an essential step in the flow of information from DNA to protein in all eukaryotes. Research over the past four decades has molecularly delineated the splicing pathway, including characterization of the detailed splicing reaction, definition of the spliceosome and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 27, 2017 Category: Cytology Authors: Yigong Shi Tags: Review Source Type: research
Ageing: Live longer with small nucleoli
Nature Reviews Molecular Cell Biology 18, 651 (2017).
doi:10.1038/nrm.2017.100
Author: Eytan Zlotorynski
The size and activity of nucleoli are cellular hallmarks of longevity and ageing, in model organisms and in humans. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 27, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
In the news: The Lasker goes to Michael Hall
Nature Reviews Molecular Cell Biology 18, 594 (2017).
doi:10.1038/nrm.2017.97
Author: Kim Baumann
The 2017 Albert Lasker Basic Medical Research Award was awarded to Michael N. Hall (Biozentrum, University of Basel, Switzerland) “for discoveries concerning the nutrient-activated TOR proteins and their central role in the metabolic control of cell growth”. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 21, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Ubiquitylation at the crossroads of development and disease
Nature Reviews Molecular Cell Biology 19, 59 (2018).
doi:10.1038/nrm.2017.83
Author: Michael Rape
Human development requires intricate cell specification and communication pathways that allow an embryo to generate and appropriately connect more than 200 different cell types. Key to the successful completion of this differentiation programme is the quantitative and reversible regulation of core signalling networks, and post-translational (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 20, 2017 Category: Cytology Authors: Michael Rape Tags: Review Source Type: research
The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis
Nature Reviews Molecular Cell Biology 19, 45 (2018).
doi:10.1038/nrm.2017.77
Author: Paul Schimmel
The discovery of the genetic code and tRNAs as decoders of the code transformed life science. However, after establishing the role of tRNAs in protein synthesis, the field moved to other parts of the RNA world. Now, tRNA research is blooming again, with demonstration of (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 6, 2017 Category: Cytology Authors: Paul Schimmel Tags: Review Source Type: research
Fluorescence nanoscopy in cell biology
Nature Reviews Molecular Cell Biology 18, 685 (2017).
doi:10.1038/nrm.2017.71
Authors: Steffen J. Sahl, Stefan W. Hell & Stefan Jakobs
Fluorescence nanoscopy uniquely combines minimally invasive optical access to the internal nanoscale structure and dynamics of cells and tissues with molecular detection specificity. While the basic physical principles of 'super-resolution' imaging were discovered in the 1990s, with initial experimental demonstrations following in 2000, the broad (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 6, 2017 Category: Cytology Authors: Steffen J. Sahl Stefan W. Hell Stefan Jakobs Tags: Review Source Type: research
Cell organization by liquid phase separation
Nature Reviews Molecular Cell Biology 18, 593 (2017).
doi:10.1038/nrm.2017.93
Author: Daniel W. Gerlich
Daniel Gerlich discusses how a study by the Hyman laboratory introduced the theory of liquid phase separation to cell biology and its implications for the understanding of cell organization and function. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 6, 2017 Category: Cytology Authors: Daniel W. Gerlich Tags: Research Highlight Source Type: research
Nuclear Envelope: Chromosomes: one BAF layer to bind them all
Nature Reviews Molecular Cell Biology 18, 592 (2017).
doi:10.1038/nrm.2017.96
Author: Paulina Strzyz
Barrier-to-autointegration factor (BAF) forms a layer on the surface of chromatin at late mitosis, guiding the reformation of a single nuclear envelope surrounding all chromosomes. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 6, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Regulation of heat shock transcription factors and their roles in physiology and disease
Nature Reviews Molecular Cell Biology 19, 4 (2018).
doi:10.1038/nrm.2017.73
Authors: Rocio Gomez-Pastor, Eileen T. Burchfiel & Dennis J. Thiele
The heat shock transcription factors (HSFs) were discovered over 30 years ago as direct transcriptional activators of genes regulated by thermal stress, encoding heat shock proteins. The accepted paradigm posited that HSFs exclusively activate the expression of protein chaperones in response to conditions that cause (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 30, 2017 Category: Cytology Authors: Rocio Gomez-Pastor Eileen T. Burchfiel Dennis J. Thiele Tags: Review Source Type: research
Cytosolic lipolysis and lipophagy: two sides of the same coin
Nature Reviews Molecular Cell Biology 18, 671 (2017).
doi:10.1038/nrm.2017.76
Authors: Rudolf Zechner, Frank Madeo & Dagmar Kratky
Fatty acids are the most efficient substrates for energy production in vertebrates and are essential components of the lipids that form biological membranes. Synthesis of triacylglycerols from non-esterified free fatty acids (FFAs) combined with triacylglycerol storage represents a highly efficient strategy to stockpile FFAs in (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 30, 2017 Category: Cytology Authors: Rudolf Zechner Frank Madeo Dagmar Kratky Tags: Review Source Type: research
Microtubule nucleation: beyond the template
Nature Reviews Molecular Cell Biology 18, 702 (2017).
doi:10.1038/nrm.2017.75
Authors: Johanna Roostalu & Thomas Surrey
Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how many microtubules are being made. Whereas the regulation of microtubule dynamics is well studied, the molecular mechanisms (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 23, 2017 Category: Cytology Authors: Johanna Roostalu Thomas Surrey Tags: Review Source Type: research
Chromosome biology: Different turfs for cohesin and condensin
Nature Reviews Molecular Cell Biology 18, 592 (2017).
doi:10.1038/nrm.2017.90
Author: Eytan Zlotorynski
In yeast, mitotic chromosome condensation is achieved by cis-chromatin looping, a process in which cohesin and condensin have distinct roles. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 23, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Genome organization: A vision of 3D chromatin organization
Nature Reviews Molecular Cell Biology 18, 532 (2017).
doi:10.1038/nrm.2017.88
Author: Kim Baumann
A new imaging technique (ChromEMT) enables the visualization of the local polymer structure and global 3D organization of chromatin in the nucleus of intact interphase and mitotic human cells. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 23, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
The essential kinase ATR: ensuring faithful duplication of a challenging genome
Nature Reviews Molecular Cell Biology 18, 622 (2017).
doi:10.1038/nrm.2017.67
Authors: Joshua C. Saldivar, David Cortez & Karlene A. Cimprich
One way to preserve a rare book is to lock it away from all potential sources of damage. Of course, an inaccessible book is also of little use, and the paper and ink will continue to degrade with age in any case. Like a book, (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 16, 2017 Category: Cytology Authors: Joshua C. Saldivar David Cortez Karlene A. Cimprich Tags: Review Source Type: research
