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Chromosome biology: TZAP trims telomeres
Nature Reviews Molecular Cell Biology 18, 140 (2017). doi:10.1038/nrm.2017.8 Author: Eytan Zlotorynski A zinc finger protein is shown to bind to telomeres and mediate telomere trimming, thereby preventing potentially detrimental telomere lengthening. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 31, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

Stem cells: A key to totipotency
Nature Reviews Molecular Cell Biology 18, 137 (2017). doi:10.1038/nrm.2017.9 Author: Kim Baumann The microRNA mir-34a has a key role in restricting the developmental potential of mouse pluripotent stem cells to embryonic cell types. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 31, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research

Mechanisms and functions of nuclear envelope remodelling
Nature Reviews Molecular Cell Biology 18, 229 (2017). doi:10.1038/nrm.2016.153 Authors: Rosemarie Ungricht & Ulrike Kutay As a compartment border, the nuclear envelope (NE) needs to serve as both a protective membrane shell for the genome and a versatile communication interface between the nucleus and the cytoplasm. Despite its important structural role in sheltering the genome, the NE is a dynamic (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 24, 2017 Category: Cytology Authors: Rosemarie Ungricht Ulrike Kutay Tags: Review Source Type: research

Translation: Ubiquitylation mediates quality control
Nature Reviews Molecular Cell Biology 18, 71 (2017). doi:10.1038/nrm.2017.6 Author: Eytan Zlotorynski Terminally stalled ribosomes can initiate degradation of nascent polypeptides and the dissociation of ribosome subunits, a process known as ribosome-associated quality control (RQC). Using a reporter that quantitatively measures ribosome terminal stalling, Juszkiewicz and Hegde found that most ribosomes in human cells stalled when they (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 23, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

Development: Metabolism regulates lymphangiogenesis
Nature Reviews Molecular Cell Biology 18, 71 (2017). doi:10.1038/nrm.2017.5 Author: Kim Baumann Wong et al. report that metabolism — more specifically, fatty acid β-oxidation (FAO) — promotes lymphatic development. They found that FAO is high in lymphatic endothelial cells (LECs; which line lymph vessels) and that inhibition or LEC-specific loss of CPT1A, which is a rate-controlling (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 23, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research

Non-Coding RNA: A class of their own
Nature Reviews Molecular Cell Biology 18, 71 (2017). doi:10.1038/nrm.2017.4 Author: Eytan Zlotorynski The transcription and processing of long intervening noncoding RNAs (lincRNAs), which are a class of lncRNAs expressed independently of protein-coding genes, are poorly understood. Schlackow et al. studied 285 lincRNAs that are highly expressed in HeLa cells using mNET-seq, which enables monitoring of the (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 23, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

Telomeres in cancer: tumour suppression and genome instability
Nature Reviews Molecular Cell Biology 18, 175 (2017). doi:10.1038/nrm.2016.171 Authors: John Maciejowski & Titia de Lange The shortening of human telomeres has two opposing effects during cancer development. On the one hand, telomere shortening can exert a tumour-suppressive effect through the proliferation arrest induced by activating the kinases ATM and ATR at unprotected chromosome ends. On the other hand, loss of (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 17, 2017 Category: Cytology Authors: John Maciejowski Titia de Lange Tags: Review Source Type: research

DNA repair: Histones have got to go
Nature Reviews Molecular Cell Biology 18, 138 (2017). doi:10.1038/nrm.2017.2 Author: Paulina Strzyz DNA damage-induced histone degradation results in decreased nucleosome occupancy, which promotes homologous recombination by enhancing the dynamicity of chromatin. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 17, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

Cell death: Pulling the apoptotic trigger for necrosis
Nature Reviews Molecular Cell Biology 18, 72 (2017). doi:10.1038/nrm.2017.1 Author: Paulina Strzyz Secondary necrosis following apoptosis induction is a regulated process that is dependent on the cleavage of DFNA5 by the executioner caspase, caspase 3. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 10, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

Translation: Smoothening the coding sequence for translation
Nature Reviews Molecular Cell Biology 18, 72 (2017). doi:10.1038/nrm.2016.178 Author: Eytan Zlotorynski A new mechanism of controlling translation initiation depends on DEAD-box RNA helicases and on RNA structures, including those present in coding sequences. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 10, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
Nature Reviews Molecular Cell Biology 18, 246 (2017). doi:10.1038/nrm.2016.143 Authors: Takao Fujisawa & Panagis Filippakopoulos Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 4, 2017 Category: Cytology Authors: Takao Fujisawa Panagis Filippakopoulos Tags: Review Source Type: research

Glucocorticoid receptor control of transcription: precision and plasticity via allostery
Nature Reviews Molecular Cell Biology 18, 159 (2017). doi:10.1038/nrm.2016.152 Authors: Emily R. Weikum, Matthew T. Knuesel, Eric A. Ortlund & Keith R. Yamamoto The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular and physiological contexts. The precision of GR-mediated responses seems to depend on combinatorial, context-specific assembly of GR-nucleated transcription regulatory complexes at (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 4, 2017 Category: Cytology Authors: Emily R. Weikum Matthew T. Knuesel Eric A. Ortlund Keith R. Yamamoto Tags: Review Source Type: research

Histone chaperone networks shaping chromatin function
Nature Reviews Molecular Cell Biology 18, 141 (2017). doi:10.1038/nrm.2016.159 Authors: Colin M. Hammond, Caroline B. Strømme, Hongda Huang, Dinshaw J. Patel & Anja Groth The association of histones with specific chaperone complexes is important for their folding, oligomerization, post-translational modification, nuclear import, stability, assembly and genomic localization. In this way, the chaperoning of soluble histones is a key determinant of histone availability and fate, which affects all chromosomal processes, (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 4, 2017 Category: Cytology Authors: Colin M. Hammond Caroline B. Str ømme Hongda Huang Dinshaw J. Patel Anja Groth Tags: Review Source Type: research

Ageing: Forever young
Nature Reviews Molecular Cell Biology 18, 70 (2017). doi:10.1038/nrm.2016.176 Author: Kim Baumann Partial reprogramming through short-term expression of OSKM reverses the ageing process in mice. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 4, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research

RNA Metabolism: Modifying sex in flies
Nature Reviews Molecular Cell Biology 18, 70 (2017). doi:10.1038/nrm.2016.173 Author: Denise Waldron Two groups report that N6-methyladenosine (m6A) affects alternative splicing in fruit files, with notable phenotypes in sex determination and the nervous system. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 4, 2017 Category: Cytology Authors: Denise Waldron Tags: Research Highlight Source Type: research