Nature Reviews Molecular Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Cell Senescence: Controlling the senescence-associated secretory phenotype
Nature Reviews Molecular Cell Biology 17, 740 (2016).
doi:10.1038/nrm.2016.157
Author: Paulina Strzyz
Cell entry into senescence is typically irreversible and is associated with heterochromatization of the genome, which is marked by the establishment of senescence-associated heterochromatin foci (SAHF). However, in contrast to many genes that are silenced on senescence entry (including pro-proliferative genes), the expression of factors (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 20, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Stem cells: Coordinated expansion of cells in the skin
Nature Reviews Molecular Cell Biology 17, 740 (2016).
doi:10.1038/nrm.2016.156
Author: Paulina Strzyz
Coordination between different cell types that comprise an organ is essential to ensure proper organ growth and remodelling during homeostasis, but how this is achieved is poorly understood. Zhang et al. used mouse skin to study how the growth of the hair follicle is (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 20, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
DNA Repair: RNA –DNA hybrids: a double-edged sword in genomic stability
Nature Reviews Molecular Cell Biology 17, 740 (2016).
doi:10.1038/nrm.2016.155
Author: Paulina Strzyz
The formation of RNA–DNA hybrids results in replicative stress and, as a consequence, the emergence of DNA double-strand breaks (DSBs). Thus, RNA–DNA hybrid formation has been primarily associated with genomic instability. The findings of Ohle et al. now change this view, implicating RNA–DNA hybrids (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 20, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
3D solutions to complex gene regulation
Nature Reviews Molecular Cell Biology 17, 739 (2016).
doi:10.1038/nrm.2016.154
Author: Edith Heard
Edith Heard describes how the discovery of lamina-associated domains changed her thinking about the mechanisms of X-chromosome inactivation and gene regulation. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 20, 2016 Category: Cytology Authors: Edith Heard Tags: Research Highlight Source Type: research
Nuclear organization: NUP-tial binding to super-enhancers
Nature Reviews Molecular Cell Biology 17, 738 (2016).
doi:10.1038/nrm.2016.158
Author: Kim Baumann
Super-enhancers interact with human nucleoporins at the nuclear pore complex to regulate cell type-specific genes. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 20, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
The roles of RNA processing in translating genotype to phenotype
Nature Reviews Molecular Cell Biology 18, 102 (2017).
doi:10.1038/nrm.2016.139
Authors: Kassie S. Manning & Thomas A. Cooper
A goal of human genetics studies is to determine the mechanisms by which genetic variation produces phenotypic differences that affect human health. Efforts in this respect have previously focused on genetic variants that affect mRNA levels by altering epigenetic and transcriptional regulation. Recent studies show (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 15, 2016 Category: Cytology Authors: Kassie S. Manning Thomas A. Cooper Tags: Review Source Type: research
Regulation of disease-associated gene expression in the 3D genome
Nature Reviews Molecular Cell Biology 17, 771 (2016).
doi:10.1038/nrm.2016.138
Authors: Peter Hugo Lodewijk Krijger & Wouter de Laat
Genetic variation associated with disease often appears in non-coding parts of the genome. Understanding the mechanisms by which this phenomenon leads to disease is necessary to translate results from genetic association studies to the clinic. Assigning function to this type of variation is notoriously difficult (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 8, 2016 Category: Cytology Authors: Peter Hugo Lodewijk Krijger Wouter de Laat Tags: Review Source Type: research
Plant cell biology: Blue light gives CRY the blues
Nature Reviews Molecular Cell Biology 17, 740 (2016).
doi:10.1038/nrm.2016.150
Author: Eytan Zlotorynski
The activity of the plant photoreceptor cryptochrome 2 is regulated by a newly characterized interacting protein that prevents cryptochrome 2 homodimerization. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 8, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Post-transcriptional gene regulation by mRNA modifications
Nature Reviews Molecular Cell Biology 18, 31 (2017).
doi:10.1038/nrm.2016.132
Authors: Boxuan Simen Zhao, Ian A. Roundtree & Chuan He
The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N6-methyladenosine (m6A) unveiled it as a modification that cells utilize to accelerate (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 2, 2016 Category: Cytology Authors: Boxuan Simen Zhao Ian A. Roundtree Chuan He Tags: Review Source Type: research
Organelle dynamics: RecovERy after stress
Nature Reviews Molecular Cell Biology 17, 738 (2016).
doi:10.1038/nrm.2016.145
Author: Paulina Strzyz
Selective autophagy that is dependent on the ER translocon component SEC62 mediates ER recovery following protein stress. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 2, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Turning the tide on 3D nuclear organization
Nature Reviews Molecular Cell Biology 17, 738 (2016).
doi:10.1038/nrm.2016.146
Author: Peter Fraser
Physically bridging an enhancer to a β-globin gene increased transcription and explained how enhancers could function over long distances. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 2, 2016 Category: Cytology Authors: Peter Fraser Tags: Research Highlight Source Type: research
Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression
Nature Reviews Molecular Cell Biology 17, 756 (2016).
doi:10.1038/nrm.2016.126
Authors: Jesse M. Engreitz, Noah Ollikainen & Mitchell Guttman
Over the past decade, it has become clear that mammalian genomes encode thousands of long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological processes. Recent work studying the molecular mechanisms of several key examples — including Xist, which orchestrates X chromosome (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - October 25, 2016 Category: Cytology Authors: Jesse M. Engreitz Noah Ollikainen Mitchell Guttman Tags: Review Source Type: research
Genome organization: Add a TAD of duplication
Nature Reviews Molecular Cell Biology 17, 737 (2016).
doi:10.1038/nrm.2016.144
Author: Eytan Zlotorynski
Genomic duplications that modify the structure and function of topologically associated domains can deregulate gene expression and cause disease without altering gene copy numbers. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - October 25, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Genome stability: Cyclin' on mRNA
Nature Reviews Molecular Cell Biology 17, 676 (2016).
doi:10.1038/nrm.2016.142
Author: Kim Baumann
Cyclin A2 ensures accurate chromosome segregation through cyclin-dependent kinase (CDK) activation, and proper DNA replication and repair through previously uncharacterized kinase-independent RNA-binding activity. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - October 19, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors
Nature Reviews Molecular Cell Biology 17, 783 (2016).
doi:10.1038/nrm.2016.122
Authors: Ellis R. Levin & Stephen R. Hammes
Steroid hormone receptors mediate numerous crucial biological processes and are classically thought to function as transcriptional regulators in the nucleus. However, it has been known for more than 50 years that steroids evoke rapid responses in many organs that cannot be explained by gene regulation. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - October 11, 2016 Category: Cytology Authors: Ellis R. Levin Stephen R. Hammes Tags: Review Source Type: research
