Nature Reviews Molecular Cell Biology 
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Nature Reviews Molecular Cell Biology 17, 676 (2016).
doi:10.1038/nrm.2016.141
Author: Paulina Strzyz
Elucidation of the mechanisms of autophagy and the work on designing molecular machines have been awarded with a 2016 Nobel Prize, in the fields of Physiology or Medicine and in Chemistry, respectively. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - October 5, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Reverse-topology membrane scission by the ESCRT proteins
Nature Reviews Molecular Cell Biology 18, 5 (2017).
doi:10.1038/nrm.2016.121
Authors: Johannes Schöneberg, Il-Hyung Lee, Janet H. Iwasa & James H. Hurley
The narrow membrane necks formed during viral, exosomal and intra-endosomal budding from membranes, as well as during cytokinesis and related processes, have interiors that are contiguous with the cytosol. Severing these necks involves action from the opposite face of the membrane as occurs during the (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - October 4, 2016 Category: Cytology Authors: Johannes Sch öneberg Il-Hyung Lee Janet H. Iwasa James H. Hurley Tags: Review Source Type: research
Origins of mass spectrometry-based proteomics
Nature Reviews Molecular Cell Biology 17, 678 (2016).
doi:10.1038/nrm.2016.135
Author: Matthias Mann
Matthias Mann describes a 1992 paper by Donald Hunt and colleagues that revolutionized the use of mass spectrometry in molecular biology. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - October 4, 2016 Category: Cytology Authors: Matthias Mann Tags: Research Highlight Source Type: research
Gene expression: Reading protein acetylation
Nature Reviews Molecular Cell Biology 17, 676 (2016).
doi:10.1038/nrm.2016.137
Author: Kirsty Minton
SET specifically binds to the unacetylated form of p53 to repress p53-mediated transcriptional activation. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - October 4, 2016 Category: Cytology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Mechanisms and in vivo functions of contact inhibition of locomotion
Nature Reviews Molecular Cell Biology 18, 43 (2017).
doi:10.1038/nrm.2016.118
Authors: Brian Stramer & Roberto Mayor
Contact inhibition of locomotion (CIL) is a process whereby a cell ceases motility or changes its trajectory upon collision with another cell. CIL was initially characterized more than half a century ago and became a widely studied model system to understand how cells migrate and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 27, 2016 Category: Cytology Authors: Brian Stramer Roberto Mayor Tags: Review Source Type: research
Alternative polyadenylation of mRNA precursors
Nature Reviews Molecular Cell Biology 18, 18 (2017).
doi:10.1038/nrm.2016.116
Authors: Bin Tian & James L. Manley
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 27, 2016 Category: Cytology Authors: Bin Tian James L. Manley Tags: Review Source Type: research
Organelle dynamics: Sizing mitochondria with phospholipids
Nature Reviews Molecular Cell Biology 17, 678 (2016).
doi:10.1038/nrm.2016.133
Author: Paulina Strzyz
The lipid composition of the mitochondrial membrane, in particular, synthesis of phosphatidic acid, regulates mitochondrial size by modulating fusion and fission cycles. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 27, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
RNA decay: Dhh1p condemns mRNAs with non-optimal codons to decay
Nature Reviews Molecular Cell Biology 17, 675 (2016).
doi:10.1038/nrm.2016.136
Author: Eytan Zlotorynski
In budding yeast, the association of Dhh1p with ribosomes on mRNAs enriched in non-optimal codons mediates their decay. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 27, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Nature Reviews Molecular Cell Biology 17, 703 (2016).
doi:10.1038/nrm.2016.111
Authors: Yves Pommier, Yilun Sun, Shar-yin N. Huang & John L. Nitiss
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove catenanes and enable chromosome segregation. Human cells encode six topoisomerases (TOP1, TOP1mt, TOP2α, TOP2β, TOP3α and TOP3β), which act on a broad range of DNA and RNA substrates at the nuclear and mitochondrial genomes. Their (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 20, 2016 Category: Cytology Authors: Yves Pommier Yilun Sun Shar-yin N. Huang John L. Nitiss Tags: Review Source Type: research
Cytoskeleton: Patching up microtubule growth
Nature Reviews Molecular Cell Biology 17, 677 (2016).
doi:10.1038/nrm.2016.131
Author: Paulina Strzyz
Microtubule depolymerization can be arrested and growth rescued at sites where the lattice is self-repaired following local damage. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 20, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Mechanotransduction: Stretching chromatin promotes transcription
Nature Reviews Molecular Cell Biology 17, 610 (2016).
doi:10.1038/nrm.2016.130
Author: Eytan Zlotorynski
Whether chromatin stretching and decondensing by physiological forces affects gene expression is unclear. Tajik et al. used 3D magnetic twisting cytometry to apply force to chromatin in Chinese hamster ovary cells carrying a genomic insertion of an array of DHFR genes. Each DHFR (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 20, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Mechanisms of disease: Metabolic reprogramming cures liver disease
Nature Reviews Molecular Cell Biology 17, 610 (2016).
doi:10.1038/nrm.2016.129
Author: Eytan Zlotorynski
Hereditary tyrosinaemia type I (HT-I) is a lethal liver disease that is caused by mutations in FAH, which encodes fumarylacetoacetate hydrolase, the enzyme that catalyses the final step of tyrosine catabolism. FAH deficiency leads to the accumulation of toxic metabolic intermediates that cause hepatocellular (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 20, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Chromosome biology: Mitotic chromatin condensin'
Nature Reviews Molecular Cell Biology 17, 610 (2016).
doi:10.1038/nrm.2016.128
Author: Eytan Zlotorynski
Kim et al. investigated the function of the SMC (structural maintenance of chromosomes) complex condensin in the organization of the fission yeast genome. The yeast condensin protein Cut14 localized to both centromeres and target genes of the transcription factors Ams2 and Ace2. Condensin formed (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 20, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Internetwork competition for monomers governs actin cytoskeleton organization
Nature Reviews Molecular Cell Biology 17, 799 (2016).
doi:10.1038/nrm.2016.106
Authors: Cristian Suarez & David R. Kovar
Cells precisely control the formation of dynamic actin cytoskeleton networks to coordinate fundamental processes, including motility, division, endocytosis and polarization. To support these functions, actin filament networks must be assembled, maintained and disassembled at the correct time and place, and with proper filament organization and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 13, 2016 Category: Cytology Authors: Cristian Suarez David R. Kovar Tags: Perspectives Source Type: research
Metabolism: Mitophagy turns beige adipocytes white
Nature Reviews Molecular Cell Biology 17, 607 (2016).
doi:10.1038/nrm.2016.125
Author: Katharine H. Wrighton
A new study shows that the beige-to-white adipocyte transition requires mitophagy. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - September 13, 2016 Category: Cytology Authors: Katharine H. Wrighton Tags: Research Highlight Source Type: research
