Mechanotransduction: Stretching chromatin promotes transcription

Nature Reviews Molecular Cell Biology 17, 610 (2016). doi:10.1038/nrm.2016.130 Author: Eytan Zlotorynski Whether chromatin stretching and decondensing by physiological forces affects gene expression is unclear. Tajik et al. used 3D magnetic twisting cytometry to apply force to chromatin in Chinese hamster ovary cells carrying a genomic insertion of an array of DHFR genes. Each DHFR

http://feeds.nature.com/~r/nrm/rss/current/~3/iaEF2oLTlOc/nrm.2016.130

Source: Nature Reviews Molecular Cell Biology - September 20, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research