Nature Reviews Molecular Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Synthetic biology: Designer cells tackle diabetes
Nature Reviews Molecular Cell Biology 18, 69 (2017).
doi:10.1038/nrm.2016.175
Author: Paulina Strzyz
Two studies report on two independent synthetic biology approaches to tackle hyperglycaemia and insulin resistance that are associated with diabetes. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - January 4, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Necroptosis in development, inflammation and disease
Nature Reviews Molecular Cell Biology 18, 127 (2017).
doi:10.1038/nrm.2016.149
Authors: Ricardo Weinlich, Andrew Oberst, Helen M. Beere & Douglas R. Green
In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a molecule already recognized as an important regulator of cell survival, inflammation and disease, was attributed an additional function: the regulation of a novel cell death pathway that came to be known as necroptosis. Subsequently, (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 20, 2016 Category: Cytology Authors: Ricardo Weinlich Andrew Oberst Helen M. Beere Douglas R. Green Tags: Perspectives Source Type: research
The nuclear pore complex: understanding its function through structural insight
Nature Reviews Molecular Cell Biology 18, 73 (2017).
doi:10.1038/nrm.2016.147
Authors: Martin Beck & Ed Hurt
Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form channels across the nuclear envelope. They are large macromolecular assemblies with a complex composition and diverse functions. Apart from facilitating nucleocytoplasmic transport, NPCs are involved in chromatin organization, the regulation of gene (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 20, 2016 Category: Cytology Authors: Martin Beck Ed Hurt Tags: Review Source Type: research
RNA decay: NoBody binds to mRNA decapping proteins
Nature Reviews Molecular Cell Biology 18, 4 (2017).
doi:10.1038/nrm.2016.170
Author: Kim Baumann
Recent studies have revealed that genomes contain thousands of small open reading frames that encode microproteins, but the functional significance of microproteins is unclear. D'Lima et al. now report the identification of a human microprotein, NoBody (non-annotated P-body dissociating polypeptide), that interacts with the (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 18, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Genome engineering: NHEJ and CRISPR –Cas9 improve gene therapy
Nature Reviews Molecular Cell Biology 18, 4 (2017).
doi:10.1038/nrm.2016.169
Author: Eytan Zlotorynski
The repair of DNA double-strand breaks by non-homologous end-joining (NHEJ) is efficient in non-dividing cells, but its use for site-specific transgene integration has not been shown. Suzuki et al. developed homology-independent targeted integration (HITI) for CRISPR–Cas9- and NHEJ-based gene knock-in. HITI successfully mediated site-directed (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 18, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Organelle dynamics: Controlling phase separation of P granules
Nature Reviews Molecular Cell Biology 18, 4 (2017).
doi:10.1038/nrm.2016.168
Author: Paulina Strzyz
Caenorhabditis elegans germ cell granules (P granules) are RNA and protein condensates that are associated with RNA metabolism. In C. elegans zygotes, P granules are spatially restricted to the posterior pole and, similarly to other non-membranous organelles, their formation is driven by liquid–liquid (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 18, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Cellular senescence: Senescence and reprogramming go hand-in-hand
Nature Reviews Molecular Cell Biology 18, 4 (2017).
doi:10.1038/nrm.2016.165
Author: Kim Baumann
OSKM-mediated reprogramming to pluripotency in vivo is facilitated by cellular senescence through the secretion of key cytokines. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 18, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Protein translocation: The third route to the ER
Nature Reviews Molecular Cell Biology 18, 3 (2017).
doi:10.1038/nrm.2016.164
Author: Paulina Strzyz
The newly identified SND pathway is an alternative route for the targeting of proteins to the endoplasmic reticulum that functions in parallel to the SRP and GET pathways. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 18, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Chromatin: The chemical brothers: nucleosomes and transcription
Nature Reviews Molecular Cell Biology 18, 2 (2017).
doi:10.1038/nrm.2016.167
Author: Eytan Zlotorynski
A chemical approach for precisely mapping nucleosomes genome-wide provides novel insights into the regulation of transcription and splicing. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 18, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Histone variants on the move: substrates for chromatin dynamics
Nature Reviews Molecular Cell Biology 18, 115 (2017).
doi:10.1038/nrm.2016.148
Authors: Paul B. Talbert & Steven Henikoff
Most histones are assembled into nucleosomes behind the replication fork to package newly synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are typically incorporated throughout the cell cycle. Histone variants can profoundly change chromatin properties, which in turn affect DNA replication (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 6, 2016 Category: Cytology Authors: Paul B. Talbert Steven Henikoff Tags: Review Source Type: research
Metabolic regulation of gene expression through histone acylations
Nature Reviews Molecular Cell Biology 18, 90 (2017).
doi:10.1038/nrm.2016.140
Authors: Benjamin R. Sabari, Di Zhang, C. David Allis & Yingming Zhao
Eight types of short-chain Lys acylations have recently been identified on histones: propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation, glutarylation, crotonylation and β-hydroxybutyrylation. Emerging evidence suggests that these histone modifications affect gene expression and are structurally and functionally different from the widely studied histone Lys acetylation. In (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 6, 2016 Category: Cytology Authors: Benjamin R. Sabari Di Zhang C. David Allis Yingming Zhao Tags: Review Source Type: research
Stem cells: HSC function determined by epigenetic memory
Nature Reviews Molecular Cell Biology 18, 1 (2017).
doi:10.1038/nrm.2016.161
Author: Kirsty Minton
The functional behaviour of haematopoietic stem cells is determined in a cell-autonomous manner by clone-specific epigenetic modifications. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 6, 2016 Category: Cytology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Cell migration: Let your fingers do the walking
Nature Reviews Molecular Cell Biology 18, 2 (2017).
doi:10.1038/nrm.2016.160
Author: Paulina Strzyz
Cadherin-based, finger-like cell–cell contacts are shown to serve as instructive structural cues that coordinate motility during collective cell migration. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 29, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
A view of human haematopoietic development from the Petri dish
Nature Reviews Molecular Cell Biology 18, 56 (2017).
doi:10.1038/nrm.2016.127
Authors: Andrea Ditadi, Christopher M. Sturgeon & Gordon Keller
Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 22, 2016 Category: Cytology Authors: Andrea Ditadi Christopher M. Sturgeon Gordon Keller Tags: Review Source Type: research
Mapping the 3D genome: Aiming for consilience
Nature Reviews Molecular Cell Biology 17, 741 (2016).
doi:10.1038/nrm.2016.151
Author: Job Dekker
The spatial organization of genomes is studied using microscopy- and chromosome conformation capture (3C)-based methods. The two types of methods produce data that are often consistent, but there are cases where they appear discordant. These cases provide opportunities to derive better models of chromatin folding, (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 20, 2016 Category: Cytology Authors: Job Dekker Tags: Comment Source Type: research
