Metabolic regulation of gene expression through histone acylations

Nature Reviews Molecular Cell Biology 18, 90 (2017). doi:10.1038/nrm.2016.140 Authors: Benjamin R. Sabari, Di Zhang, C. David Allis & Yingming Zhao Eight types of short-chain Lys acylations have recently been identified on histones: propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation, glutarylation, crotonylation and β-hydroxybutyrylation. Emerging evidence suggests that these histone modifications affect gene expression and are structurally and functionally different from the widely studied histone Lys acetylation. In
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research