Nature Reviews Molecular Cell Biology 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Circadian rhythms: Replication keeps the clock ticking
Nature Reviews Molecular Cell Biology 18, 468 (2017).
doi:10.1038/nrm.2017.69
Author: Paulina Strzyz
DNA replication regulates nucleosome dynamics at the promoter of a negative element of the circadian clock, thereby providing regulatory feedback into circadian rhythms. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 5, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Stem cells: Colonic organoids for drug testing and colorectal disease modelling
Nature Reviews Molecular Cell Biology 18, 467 (2017).
doi:10.1038/nrm.2017.70
Author: Kim Baumann
Two studies report the generation of human colonic organoids, which could be useful for disease modelling and drug testing. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 5, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Mechanisms of DNA – protein crosslink repair
Nature Reviews Molecular Cell Biology 18, 563 (2017).
doi:10.1038/nrm.2017.56
Authors: Julian Stingele, Roberto Bellelli & Simon J. Boulton
Covalent DNA–protein crosslinks (DPCs, also known as protein adducts) of topoisomerases and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that induce DPCs include widely used classes of chemotherapeutics. Their bulkiness blocks virtually every chromatin-based process and makes them intractable (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 28, 2017 Category: Cytology Authors: Julian Stingele Roberto Bellelli Simon J. Boulton Tags: Review Source Type: research
Cancer biology: Therapy-induced transcription is cryptically widespread
Nature Reviews Molecular Cell Biology 18, 469 (2017).
doi:10.1038/nrm.2017.64
Author: Darren J. Burgess
Inhibitors of DNA methyltransferases and of histone deacetylases induce transcription from cryptic transposable elements, which results in 5′-truncated and mis-spliced proteins that may increase cancer immunogenicity. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 28, 2017 Category: Cytology Authors: Darren J. Burgess Tags: Research Highlight Source Type: research
Chromosome biology: Structuring interphase chromatin
Nature Reviews Molecular Cell Biology 18, 468 (2017).
doi:10.1038/nrm.2017.65
Author: Eytan Zlotorynski
The oligomerization of scaffold attachment factor A through its binding to chromatin-associated RNAs regulates the structure of interphase chromosomes. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 28, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Ribosome cycle emerges from DNA replication
Nature Reviews Molecular Cell Biology 18, 470 (2017).
doi:10.1038/nrm.2017.59
Author: Raymond Kaempfer
A modification of Meselson and Stahl's density gradient centrifugation method and a rare Texan yeast helped show that eukaryotic ribosomes dissociate and reform during translation. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 14, 2017 Category: Cytology Authors: Raymond Kaempfer Tags: Research Highlight Source Type: research
Translation: RAPping with ribosomes
Nature Reviews Molecular Cell Biology 18, 406 (2017).
doi:10.1038/nrm.2017.62
Author: Paulina Strzyz
Various proteins interact with ribosomes — this ribosome–protein interactome functionally diversifies ribosomes, thereby providing an additional means of translation regulation. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 14, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Gene expression: ACSS2 boosts local histone acetylation
Nature Reviews Molecular Cell Biology 18, 405 (2017).
doi:10.1038/nrm.2017.61
Author: Eytan Zlotorynski
During metabolic stress in cancer cells, ACSS2 binds to TFEB to locally boost the production of acetyl-CoA, thereby facilitating the expression of lysosomal and autophagy genes. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 7, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Cytoplasmic movements outside the living cell
Nature Reviews Molecular Cell Biology 18, 406 (2017).
doi:10.1038/nrm.2017.54
Author: Thomas D. Pollard
Thomas D. Pollard discusses the early work of Thompson and Wolpert on cytoplasmic extract from amoebae, which laid the foundation for studies of actin-driven cell motility. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 31, 2017 Category: Cytology Authors: Thomas D. Pollard Tags: Research Highlight Source Type: research
Transcription: Paused means poised
Nature Reviews Molecular Cell Biology 18, 404 (2017).
doi:10.1038/nrm.2017.57
Author: Eytan Zlotorynski
Promoter-proximal pausing of RNA polymerase II inhibits transcription reinitiation, especially in genes with lower steady-state expression levels. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 31, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Autophagy: Membrane contacts lend a hand
Nature Reviews Molecular Cell Biology 18, 404 (2017).
doi:10.1038/nrm.2017.55
Author: Paulina Strzyz
Extended synaptotagmins that tether ER and cell membranes also promote autophagy by regulating phosphoinositide 3-kinase. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 31, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Understanding nucleosome dynamics and their links to gene expression and DNA replication
Nature Reviews Molecular Cell Biology 18, 548 (2017).
doi:10.1038/nrm.2017.47
Authors: William K. M. Lai & B. Franklin Pugh
Advances in genomics technology have provided the means to probe myriad chromatin interactions at unprecedented spatial and temporal resolution. This has led to a profound understanding of nucleosome organization within the genome, revealing that nucleosomes are highly dynamic. Nucleosome dynamics are governed by a complex (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 24, 2017 Category: Cytology Authors: William K. M. Lai B. Franklin Pugh Tags: Review Source Type: research
Mechanisms of DNA replication termination
Nature Reviews Molecular Cell Biology 18, 507 (2017).
doi:10.1038/nrm.2017.42
Authors: James M. Dewar & Johannes C. Walter
Genome duplication is carried out by pairs of replication forks that assemble at origins of replication and then move in opposite directions. DNA replication ends when converging replication forks meet. During this process, which is known as replication termination, DNA synthesis is completed, the replication (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 24, 2017 Category: Cytology Authors: James M. Dewar Johannes C. Walter Tags: Review Source Type: research
Vascular heterogeneity and specialization in development and disease
Nature Reviews Molecular Cell Biology 18, 477 (2017).
doi:10.1038/nrm.2017.36
Authors: Michael Potente & Taija Mäkinen
Blood and lymphatic vessels pervade almost all body tissues and have numerous essential roles in physiology and disease. The inner lining of these networks is formed by a single layer of endothelial cells, which is specialized according to the needs of the tissue that it (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 24, 2017 Category: Cytology Authors: Michael Potente Taija M ä kinen Tags: Review Source Type: research
Physiological functions of programmed DNA breaks in signal-induced transcription
Nature Reviews Molecular Cell Biology 18, 471 (2017).
doi:10.1038/nrm.2017.43
Authors: Janusz Puc, Aneel K. Aggarwal & Michael G. Rosenfeld
The idea that signal-dependent transcription might involve the generation of transient DNA nicks or even breaks in the regulatory regions of genes, accompanied by activation of DNA damage repair pathways, would seem to be counterintuitive, as DNA damage is usually considered harmful to cellular integrity. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 24, 2017 Category: Cytology Authors: Janusz Puc Aneel K. Aggarwal Michael G. Rosenfeld Tags: Progress Source Type: research
