Autophagy: Inflammatory pathology of Fanconi anaemia
Nature Reviews Molecular Cell Biology 17, 330 (2016). doi:10.1038/nrm.2016.64 Author: Kirsty Minton The Fanconi anaemia DNA repair pathway also has cytoplasmic functions in selective autophagy that might contribute to Fanconi anaemia disease. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 10, 2016 Category: Cytology Authors: Kirsty Minton Tags: Research Highlight Source Type: research

The Fanconi anaemia pathway: new players and new functions
Nature Reviews Molecular Cell Biology 17, 337 (2016). doi:10.1038/nrm.2016.48 Authors: Raphael Ceccaldi, Prabha Sarangi & Alan D. D'Andrea The Fanconi anaemia pathway repairs DNA interstrand crosslinks (ICLs) in the genome. Our understanding of this complex pathway is still evolving, as new components continue to be identified and new biochemical systems are used to elucidate the molecular steps of repair. The Fanconi anaemia pathway (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 4, 2016 Category: Cytology Authors: Raphael CeccaldiPrabha SarangiAlan D. D'Andrea Tags: Review Source Type: research

DNA Replication: Looping smoothens repetitive DNA replication
Nature Reviews Molecular Cell Biology 17, 332 (2016). doi:10.1038/nrm.2016.61 Author: Kim Baumann DNA supercoiling and the formation of loops suppresses the ATR checkpoint and is required for proper replication of centromeric DNA. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 4, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research

Non-coding RNA: LINP1 joins ends with triple-negative effect
Nature Reviews Molecular Cell Biology 17, 330 (2016). doi:10.1038/nrm.2016.60 Author: Eytan Zlotorynski The long non-coding RNA LINP1 facilitates double-strand break repair in triple-negative breast cancer through non-homologous end joining, by recruiting DNA-PKcs to sites of damage. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 4, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

DNA damage response: Controlling ubiquitylation at DNA lesions
Nature Reviews Molecular Cell Biology 17, 329 (2016). doi:10.1038/nrm.2016.59 Author: Paulina Strzyz Two studies now provide new insights into the complex and multi-level regulation of ubiquitylation in the DNA damage response. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 4, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research