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Lipid Metabolism: Cholesterol feeds into cell growth control
Nature Reviews Molecular Cell Biology 18, 277 (2017). doi:10.1038/nrm.2017.41 Author: Paulina Strzyz mTORC1 is a master regulator of cell growth, which responds to nutrient availability — in particular, amino acids. Castellano et al. now show that mTORC1 is also regulated by cholesterol, suggesting a strong link between sterol metabolism and cell growth control. Cholesterol is metabolized (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 5, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

DNA Damage Response: RNA m6A regulates DNA repair
Nature Reviews Molecular Cell Biology 18, 277 (2017). doi:10.1038/nrm.2017.40 Author: Eytan Zlotorynski Xiang et al. screened human cell lines for chromatin-associated factors that participate in the DNA damage response. Ultraviolet (UV) irradiation caused rapid and transient methylation at the 6 position of adenosine (m6A), predominantly in 5′ untranslated regions of poly(A)+ RNA, (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 5, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

Cell Senescence: A new role for ATM
Nature Reviews Molecular Cell Biology 18, 277 (2017). doi:10.1038/nrm.2017.39 Author: Paulina Strzyz Cell senescence is associated with permanent withdrawal from the cell cycle in response to various stresses and ageing. Kang et al. screened human fibroblasts for factors that alleviate senescence and identified the major DNA damage repair kinase ATM as one of the hits. ATM (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 5, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

Stress Responses: Membrane-to-nucleus signals modulate plant cold tolerance
Nature Reviews Molecular Cell Biology 18, 276 (2017). doi:10.1038/nrm.2017.38 Author: Kim Baumann Cold stress activates Arabidopsis thaliana plasma membrane-localized CRPK1, which leads to 14-3-3 proteins entering the nucleus and promoting the degradation of CBF transcription factors, thus attenuating the cold-induced response. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 5, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research

Epigenetics: Cytosolic EZH1 muscles PRC2 out of the nucleus
Nature Reviews Molecular Cell Biology 18, 276 (2017). doi:10.1038/nrm.2017.37 Author: Eytan Zlotorynski In mouse muscle cells, an isoform of EZH1 — a subunit of Polycomb repressive complex 2 (PRC2) — sequesters another subunit in the cytosol, thereby inhibiting PRC2 function. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 5, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

The mystery of membrane organization: composition, regulation and roles of lipid rafts
Nature Reviews Molecular Cell Biology 18, 361 (2017). doi:10.1038/nrm.2017.16 Authors: Erdinc Sezgin, Ilya Levental, Satyajit Mayor & Christian Eggeling Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large number of studies have focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - March 30, 2017 Category: Cytology Authors: Erdinc Sezgin Ilya Levental Satyajit Mayor Christian Eggeling Tags: Review Source Type: research

Plant cell development: Forcing cell polarity
Nature Reviews Molecular Cell Biology 18, 278 (2017). doi:10.1038/nrm.2017.34 Author: Paulina Strzyz Mechanical tension is shown to contribute to the establishment of the cell polarity axis in plant epidermal stem cells, which is important for regulating asymmetric cell division. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - March 30, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

Coming to grips with cell surface polarity
Nature Reviews Molecular Cell Biology 18, 278 (2017). doi:10.1038/nrm.2017.32 Author: Kai Simons Kai Simons discusses how MDCK cells grown on semi-permeable filters have become a model for studying apico-basal cell polarity with the use of viruses. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - March 30, 2017 Category: Cytology Authors: Kai Simons Tags: Research Highlight Source Type: research