Nature Reviews Molecular Cell Biology 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Cancer biology: The skin's power of elimination
Nature Reviews Molecular Cell Biology 18, 594 (2017).
doi:10.1038/nrm.2017.85
Author: Paulina Strzyz
The skin is able to counteract tissue aberrancies resulting from tissue overgrowth and to restore normal tissue architecture by eliminating aberrant cells. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 16, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Genome editing: CRISPR – Cas becoming more human
Nature Reviews Molecular Cell Biology 18, 591 (2017).
doi:10.1038/nrm.2017.84
Author: Kim Baumann
CRISPR–Cas9 was used in human embryos to correct a dominant heterozygous gene mutation that causes hypertrophic cardiomyopathy. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 16, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Mitochondrial diseases: the contribution of organelle stress responses to pathology
Nature Reviews Molecular Cell Biology 19, 77 (2018).
doi:10.1038/nrm.2017.66
Authors: Anu Suomalainen & Brendan J. Battersby
Mitochondrial diseases affect one in 2,000 individuals; they can present at any age and they can manifest in any organ. How defects in mitochondria can cause such a diverse range of human diseases remains poorly understood. Insight into this diversity is emerging from recent research (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 9, 2017 Category: Cytology Authors: Anu Suomalainen Brendan J. Battersby Tags: Review Source Type: research
Splicing and transcription touch base: co-transcriptional spliceosome assembly and function
Nature Reviews Molecular Cell Biology 18, 637 (2017).
doi:10.1038/nrm.2017.63
Authors: Lydia Herzel, Diana S. M. Ottoz, Tara Alpert & Karla M. Neugebauer
Several macromolecular machines collaborate to produce eukaryotic messenger RNA. RNA polymerase II (Pol II) translocates along genes that are up to millions of base pairs in length and generates a flexible RNA copy of the DNA template. This nascent RNA harbours introns that are removed (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 9, 2017 Category: Cytology Authors: Lydia Herzel Diana S. M. Ottoz Tara Alpert Karla M. Neugebauer Tags: Review Source Type: research
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
Nature Reviews Molecular Cell Biology 18, 595 (2017).
doi:10.1038/nrm.2017.68
Authors: Nard Kubben & Tom Misteli
Ageing is the predominant risk factor for many common diseases. Human premature ageing diseases are powerful model systems to identify and characterize cellular mechanisms that underpin physiological ageing. Their study also leads to a better understanding of the causes, drivers and potential therapeutic strategies of (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 9, 2017 Category: Cytology Authors: Nard Kubben Tom Misteli Tags: Review Source Type: research
Stress responses: SIRT1 puts an embargo on mRNA export
Nature Reviews Molecular Cell Biology 18, 530 (2017).
doi:10.1038/nrm.2017.82
Author: Paulina Strzyz
Sirtuin 1 deacetylates polyadenylate-binding protein 1 (PABP1), thereby suppressing nuclear export of polyadenylated mRNAs and translation to preserve energy under stress. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 9, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Cancer biology: A Neat target of p53
Nature Reviews Molecular Cell Biology 18, 532 (2017).
doi:10.1038/nrm.2017.80
Author: Eytan Zlotorynski
The lincRNA Neat1 is a p53 target gene that can suppress the initiation of pancreatic cancer. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 2, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Epigenetics: Getting instructions from mum
Nature Reviews Molecular Cell Biology 18, 531 (2017).
doi:10.1038/nrm.2017.81
Author: Paulina Strzyz
Patterns of histone H3 Lys27 trimethylation are maternally inherited in both fly and mammalian embryos, and control gene expression during early development. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 2, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Adult stem cells: Fat cells promote blood regeneration
Nature Reviews Molecular Cell Biology 18, 530 (2017).
doi:10.1038/nrm.2017.79
Author: Kim Baumann
Following irradiation, adipocytes derived from a specified subset of leptin receptor-positive cells in the bone marrow become a major source of stem cell factor for haematopoietic regeneration. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 26, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Splicing: Phasing alternative exons
Nature Reviews Molecular Cell Biology 18, 529 (2017).
doi:10.1038/nrm.2017.78
Author: Eytan Zlotorynski
Two papers report a new mechanism of controlling alternative splicing through phase separation-mediated formation of higher-order assemblies of splicing factors. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 26, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Unfolded protein response: Reacting to membrane stress
Nature Reviews Molecular Cell Biology 18, 471 (2017).
doi:10.1038/nrm.2017.74
Author: Paulina Strzyz
Changes in endoplasmic reticulum membrane composition induce the oligomerization of Ire1 and activate the unfolded protein response. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 21, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Classification and function of small open reading frames
Nature Reviews Molecular Cell Biology 18, 575 (2017).
doi:10.1038/nrm.2017.58
Authors: Juan-Pablo Couso & Pedro Patraquim
Small open reading frames (smORFs) of 100 codons or fewer are usually — if arbitrarily — excluded from proteome annotations. Despite this, the genomes of many metazoans, including humans, contain millions of smORFs, some of which fulfil key physiological functions. Recently, the transcriptome of Drosophila (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 12, 2017 Category: Cytology Authors: Juan-Pablo Couso Pedro Patraquim Tags: Analysis Source Type: research
Genes and molecular pathways underpinning ciliopathies
Nature Reviews Molecular Cell Biology 18, 533 (2017).
doi:10.1038/nrm.2017.60
Authors: Jeremy F. Reiter & Michel R. Leroux
Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The dysfunction of cilia causes diseases known as ciliopathies. The number of reported ciliopathies (currently 35) is increasing, as is the number of established (187) and candidate (241) ciliopathy-associated genes. The characterization of ciliopathy-associated proteins (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 12, 2017 Category: Cytology Authors: Jeremy F. Reiter Michel R. Leroux Tags: Review Source Type: research
Transcriptional and epigenetic control of brown and beige adipose cell fate and function
Nature Reviews Molecular Cell Biology 18, 527 (2017).
doi:10.1038/nrm.2017.72
Author: Takeshi Inagaki, Juro Sakai & Shingo Kajimura
Nature Reviews Molecular Cell Biology17, 480–495 (2016)Two errors in Table 1 of the HTML and PDF versions of this article have been corrected. In addition, corrections to a number of protein definitions have been made. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 12, 2017 Category: Cytology Authors: Takeshi Inagaki Juro Sakai Shingo Kajimura Tags: Corrigendum Source Type: research
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Nature Reviews Molecular Cell Biology 18, 610 (2017).
doi:10.1038/nrm.2017.53
Authors: Arnab Ray Chaudhuri & André Nussenzweig
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways and in the (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 5, 2017 Category: Cytology Authors: Arnab Ray Chaudhuri Andr é Nussenzweig Tags: Review Source Type: research
