The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

Nature Reviews Molecular Cell Biology 18, 610 (2017).
doi:10.1038/nrm.2017.53

Authors: Arnab Ray Chaudhuri & André Nussenzweig
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways and in the

Source: Nature Reviews Molecular Cell Biology - July 5, 2017 Category: Cytology Authors: Arnab Ray Chaudhuri Andr é Nussenzweig Tags: Review Source Type: research