Nature Reviews Molecular Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The winding path of protein methylation research: milestones and new frontiers
Nature Reviews Molecular Cell Biology 18, 517 (2017).
doi:10.1038/nrm.2017.35
Authors: Jernej Murn & Yang Shi
In 1959, while analysing the bacterial flagellar proteins, Ambler and Rees observed an unknown species of amino acid that they eventually identified as methylated lysine. Over half a century later, protein methylation is known to have a regulatory role in many essential cellular processes that (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 17, 2017 Category: Cytology Authors: Jernej Murn Yang Shi Tags: Perspectives Source Type: research
Non-homologous DNA end joining and alternative pathways to double-strand break repair
Nature Reviews Molecular Cell Biology 18, 495 (2017).
doi:10.1038/nrm.2017.48
Authors: Howard H. Y. Chang, Nicholas R. Pannunzio, Noritaka Adachi & Michael R. Lieber
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous DNA end joining (NHEJ) pathway. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 17, 2017 Category: Cytology Authors: Howard H. Y. Chang Nicholas R. Pannunzio Noritaka Adachi Michael R. Lieber Tags: Review Source Type: research
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Nature Reviews Molecular Cell Biology 18, 407 (2017).
doi:10.1038/nrm.2017.26
Authors: Cedric R. Clapier, Janet Iwasa, Bradley R. Cairns & Craig L. Peterson
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out histone sliding, ejection or the incorporation of histone variants, suggesting that different mechanisms of action are used by the various chromatin-remodelling complex subfamilies. However, all chromatin-remodelling complex subfamilies contain an ATPase–translocase 'motor' that translocates DNA from (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 17, 2017 Category: Cytology Authors: Cedric R. Clapier Janet Iwasa Bradley R. Cairns Craig L. Peterson Tags: Review Source Type: research
Stem cells: Stem cell-based therapies threatened by the accumulation of p53 mutations
Nature Reviews Molecular Cell Biology 18, 403 (2017).
doi:10.1038/nrm.2017.52
Author: Kim Baumann
Cultured pluripotent stem cells can accumulate TP53 mutations, and these mutations confer a strong selective advantage to these cells. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 17, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Protein O-GlcNAcylation: emerging mechanisms and functions
Nature Reviews Molecular Cell Biology 18, 452 (2017).
doi:10.1038/nrm.2017.22
Authors: Xiaoyong Yang & Kevin Qian
O-GlcNAcylation — the attachment of O-linked N-acetylglucosamine (O-GlcNAc) moieties to cytoplasmic, nuclear and mitochondrial proteins — is a post-translational modification that regulates fundamental cellular processes in metazoans. A single pair of enzymes — O-GlcNAc transferase (OGT) and O-GlcNAcase (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 10, 2017 Category: Cytology Authors: Xiaoyong Yang Kevin Qian Tags: Review Source Type: research
Alternative splicing as a regulator of development and tissue identity
Nature Reviews Molecular Cell Biology 18, 437 (2017).
doi:10.1038/nrm.2017.27
Authors: Francisco E. Baralle & Jimena Giudice
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 10, 2017 Category: Cytology Authors: Francisco E. Baralle Jimena Giudice Tags: Review Source Type: research
Mechanisms of diseases: Excessive polyQ tracts curb autophagy
Nature Reviews Molecular Cell Biology 18, 344 (2017).
doi:10.1038/nrm.2017.50
Author: Paulina Strzyz
Expansion of polyglutamine tracts in proteins interferes with the process of autophagy and may contribute to the pathology of neurodegenerative diseases. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 10, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
RNA decay: The anti-apoptotic function of ADAR1
Nature Reviews Molecular Cell Biology 18, 343 (2017).
doi:10.1038/nrm.2017.51
Author: Eytan Zlotorynski
An isoform of the RNA-editing protein ADAR1 is shown to be activated through nuclear export in response to cellular stress and to protect anti-apoptotic mRNAs from Staufen 1-mediated decay. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 10, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Charting the unknown epitranscriptome
Nature Reviews Molecular Cell Biology 18, 339 (2017).
doi:10.1038/nrm.2017.49
Authors: Eva Maria Novoa, Christopher E. Mason & John S. Mattick
RNA modifications can alter RNA structure–function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the distribution, location (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 10, 2017 Category: Cytology Authors: Eva Maria Novoa Christopher E. Mason John S. Mattick Tags: Comment Source Type: research
The HSP90 chaperone machinery
Nature Reviews Molecular Cell Biology 18, 345 (2017).
doi:10.1038/nrm.2017.20
Authors: Florian H. Schopf, Maximilian M. Biebl & Johannes Buchner
The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells. As HSP90 has several hundred protein substrates (or 'clients'), it is involved in many cellular processes beyond protein folding, which include DNA (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 21, 2017 Category: Cytology Authors: Florian H. Schopf Maximilian M. Biebl Johannes Buchner Tags: Review Source Type: research
Cell death: ESCRTing dying cells back to life
Nature Reviews Molecular Cell Biology 18, 342 (2017).
doi:10.1038/nrm.2017.46
Author: Paulina Strzyz
The ESCRT-III complex is shown to counteract the loss of plasma membrane integrity in cells undergoing necroptosis, thereby preventing or delaying cell death. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 21, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Ageing: Is fat a key to longevity?
Nature Reviews Molecular Cell Biology 18, 341 (2017).
doi:10.1038/nrm.2017.45
Author: Kim Baumann
Worms with impaired H3K4 trimethylation have an extended lifespan, which is associated with the accumulation of monounsaturated fatty acids in their intestines. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 21, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
The development and functions of multiciliated epithelia
Nature Reviews Molecular Cell Biology 18, 423 (2017).
doi:10.1038/nrm.2017.21
Authors: Nathalie Spassky & Alice Meunier
Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for the proper function of major organs including the brain, the respiratory system and the reproductive tracts. Their multiple motile cilia beat unidirectionally to remove particles of external origin from (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 12, 2017 Category: Cytology Authors: Nathalie Spassky Alice Meunier Tags: Review Source Type: research
The moment when translational control had a theory of everything
Nature Reviews Molecular Cell Biology 18, 344 (2017).
doi:10.1038/nrm.2017.33
Author: Allan Jacobson
Allan Jacobson reminds us of how a study by Dever et al. published in 1992 connected several data on translational regulation, bringing attention to its crucial role in the regulation of gene expression. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 12, 2017 Category: Cytology Authors: Allan Jacobson Tags: Research Highlight Source Type: research
Metabolism: Methyl groups sink into phospholipids and histones
Nature Reviews Molecular Cell Biology 18, 342 (2017).
doi:10.1038/nrm.2017.44
Author: Paulina Strzyz
Phospholipids and histones act as sinks for methyl groups, thereby regulating methylation reactions and contributing to metabolic homeostasis. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - April 12, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
