Nature Reviews Molecular Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Cell signalling: Signalling to cell cycle arrest
Nature Reviews Molecular Cell Biology 17, 536 (2016).
doi:10.1038/nrm.2016.108
Author: Paulina Strzyz
Three independent studies provide molecular insights into the mechanism governing cell cycle arrest in response to centrosome loss. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 9, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Translation: Profiling ribosome dynamics
Nature Reviews Molecular Cell Biology 17, 535 (2016).
doi:10.1038/nrm.2016.109
Author: Eytan Zlotorynski
A new method, translation complex profile sequencing (TCP-seq), enables the study of translation regulation and dynamics in live cells. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 9, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Cell signalling: The motif behind PP2A –B56 specificity
Nature Reviews Molecular Cell Biology 17, 534 (2016).
doi:10.1038/nrm.2016.107
Author: Katharine H. Wrighton
A study now shows that PP2A–B56 achieves specificity by binding to a LxxIxE motif. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 9, 2016 Category: Cytology Authors: Katharine H. Wrighton Tags: Research Highlight Source Type: research
Structural insights into the catalysis and regulation of E3 ubiquitin ligases
Nature Reviews Molecular Cell Biology 17, 626 (2016).
doi:10.1038/nrm.2016.91
Authors: Lori Buetow & Danny T. Huang
Covalent attachment (conjugation) of one or more ubiquitin molecules to protein substrates governs numerous eukaryotic cellular processes, including apoptosis, cell division and immune responses. Ubiquitylation was originally associated with protein degradation, but it is now clear that ubiquitylation also mediates processes such as protein–protein interactions (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 2, 2016 Category: Cytology Authors: Lori Buetow Danny T. Huang Tags: Review Source Type: research
Mechanisms and regulation of endothelial VEGF receptor signalling
Nature Reviews Molecular Cell Biology 17, 611 (2016).
doi:10.1038/nrm.2016.87
Authors: Michael Simons, Emma Gordon & Lena Claesson-Welsh
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely required to balance the formation of new blood vessels with the maintenance and remodelling of existing ones, during development and in adult tissues. Recent advances have greatly expanded our understanding of the tight and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 26, 2016 Category: Cytology Authors: Michael Simons Emma Gordon Lena Claesson-Welsh Tags: Review Source Type: research
Actin assembly: never forget rate constants
Nature Reviews Molecular Cell Biology 17, 536 (2016).
doi:10.1038/nrm.2016.98
Author: Laurent Blanchoin
Laurent Blanchoin reminds us of a seminal paper by Tom Pollard reporting the meticulous measurement of rate constants of actin assembly, and highlights its contribution to quantitative understanding of actin filament dynamics as well as its impact on his own research interests. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 26, 2016 Category: Cytology Authors: Laurent Blanchoin Tags: Research Highlight Source Type: research
Mechanotransduction: May the force be with you
Nature Reviews Molecular Cell Biology 17, 533 (2016).
doi:10.1038/nrm.2016.105
Author: Paulina Strzyz
Mechanical strain, transmitted by the remodelling of the actomyosin cytoskeleton and concomitant depletion of the nuclear actin pool, is shown to induce silencing of differentiation genes in epidermal stem cells, linking mechanical cues to the genetic regulation of cell fate. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 26, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Development: Eliminating paternal mitochondria
Nature Reviews Molecular Cell Biology 17, 464 (2016).
doi:10.1038/nrm.2016.99
Author: Kim Baumann
The endonuclease CPS-6 mediates the degradation of paternal mitochondrial DNA and promotes paternal mitochondrial elimination through autophagy in Caenorhabditis elegans. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 20, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Quality control: Triaging mitochondrial membrane proteins
Nature Reviews Molecular Cell Biology 17, 463 (2016).
doi:10.1038/nrm.2016.103
Author: Kim Baumann
Mitochondrial membrane proteins that are imported from the cytosol contain insoluble transmembrane domains (TMDs) and thus rely on factors to prevent their aggregation in the cytosol and to route them for degradation upon import failure. Hegde and colleagues report that ubiquilins (UBQLNs) perform this function. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 20, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Nuclear organization: Building nuclear bodies with RNA
Nature Reviews Molecular Cell Biology 17, 463 (2016).
doi:10.1038/nrm.2016.102
Author: Katharine H. Wrighton
Several long non-coding RNAs function as scaffolds in the construction of nuclear bodies. Mannen et al. sought novel nuclear bodies containing such 'architectural RNA' (arcRNA). The proteins DBC1, HNRNPD, HNRNPL, ZNF346 and SAM68 localized to SAM68 nuclear bodies (SNBs). SNBs disappeared in the presence (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 20, 2016 Category: Cytology Authors: Katharine H. Wrighton Tags: Research Highlight Source Type: research
Gene expression: Promoters as spiked enhancers
Nature Reviews Molecular Cell Biology 17, 463 (2016).
doi:10.1038/nrm.2016.101
Author: Eytan Zlotorynski
Sequence determinants that distinguish between promoter and enhancer activities are poorly characterized. Nguyen et al. used massive parallel promoter and enhancer reporter assays in mouse cortical neurons to examine the activities of multiple short (139 bp) sequences that cover hundreds of conserved promoters and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 20, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Metabolism: MAD interactions with insulin receptor
Nature Reviews Molecular Cell Biology 17, 462 (2016).
doi:10.1038/nrm.2016.97
Author: Paulina Strzyz
Proteins of the mitotic checkpoint regulate insulin receptor internalization through clathrin-mediated endocytosis, thereby modulating insulin signalling and systemic glucose metabolism. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 20, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Chromosome biology: Keeping chromosomes apart
Nature Reviews Molecular Cell Biology 17, 462 (2016).
doi:10.1038/nrm.2016.95
Author: Katharine H. Wrighton
The proliferation marker Ki67 acts like a biological surfactant to keep mitotic chromosomes separate in the cytoplasm. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 20, 2016 Category: Cytology Authors: Katharine H. Wrighton Tags: Research Highlight Source Type: research
A comprehensive compilation of SUMO proteomics
Nature Reviews Molecular Cell Biology 17, 581 (2016).
doi:10.1038/nrm.2016.81
Authors: Ivo A. Hendriks & Alfred C. O. Vertegaal
Small ubiquitin-like modifiers (SUMOs) are essential for the regulation of several cellular processes and are potential therapeutic targets owing to their involvement in diseases such as cancer and Alzheimer disease. In the past decade, we have witnessed a rapid expansion of proteomic approaches for identifying (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 19, 2016 Category: Cytology Authors: Ivo A. Hendriks Alfred C. O. Vertegaal Tags: Analysis Source Type: research
Transcription –replication conflicts: how they occur and how they are resolved
Nature Reviews Molecular Cell Biology 17, 553 (2016).
doi:10.1038/nrm.2016.88
Authors: Tatiana García-Muse & Andrés Aguilera
The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, between the transcription and replication machineries. These conflicts constitute a major intrinsic source of genome instability, which is a hallmark of cancer cells. How the replication machinery progresses (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - July 19, 2016 Category: Cytology Authors: Tatiana Garc ía-Muse Andr és Aguilera Tags: Review Source Type: research
