Transcription –replication conflicts: how they occur and how they are resolved

Nature Reviews Molecular Cell Biology 17, 553 (2016). doi:10.1038/nrm.2016.88 Authors: Tatiana García-Muse & Andrés Aguilera The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, between the transcription and replication machineries. These conflicts constitute a major intrinsic source of genome instability, which is a hallmark of cancer cells. How the replication machinery progresses
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research