Quality control: Triaging mitochondrial membrane proteins

Nature Reviews Molecular Cell Biology 17, 463 (2016). doi:10.1038/nrm.2016.103 Author: Kim Baumann Mitochondrial membrane proteins that are imported from the cytosol contain insoluble transmembrane domains (TMDs) and thus rely on factors to prevent their aggregation in the cytosol and to route them for degradation upon import failure. Hegde and colleagues report that ubiquilins (UBQLNs) perform this function.
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Research Highlight Source Type: research