Quality control: Triaging mitochondrial membrane proteins
Nature Reviews Molecular Cell Biology 17, 463 (2016).
doi:10.1038/nrm.2016.103
Author: Kim Baumann
Mitochondrial membrane proteins that are imported from the cytosol contain insoluble transmembrane domains (TMDs) and thus rely on factors to prevent their aggregation in the cytosol and to route them for degradation upon import failure. Hegde and colleagues report that ubiquilins (UBQLNs) perform this function.
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research