Nature Reviews Molecular Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Translation: Live stream: translation at single-mRNA resolution
Nature Reviews Molecular Cell Biology 17, 395 (2016).
doi:10.1038/nrm.2016.78
Author: Eytan Zlotorynski
Four research groups have developed, independently, an imaging technique that enables us, for the first time, to track and study the translation of single mRNA molecules in living cells. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 7, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Transcriptional and epigenetic control of brown and beige adipose cell fate and function
Nature Reviews Molecular Cell Biology 17, 480 (2016).
doi:10.1038/nrm.2016.62
Authors: Takeshi Inagaki, Juro Sakai & Shingo Kajimura
White adipocytes store excess energy in the form of triglycerides, whereas brown and beige adipocytes dissipate energy in the form of heat. This thermogenic function relies on the activation of brown and beige adipocyte-specific gene programmes that are coordinately regulated by adipose-selective chromatin architectures and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 1, 2016 Category: Cytology Authors: Takeshi Inagaki Juro Sakai Shingo Kajimura Tags: Review Source Type: research
The multiple functions of RNA helicases as drivers and regulators of gene expression
Nature Reviews Molecular Cell Biology 17, 426 (2016).
doi:10.1038/nrm.2016.50
Authors: Cyril F. Bourgeois, Franck Mortreux & Didier Auboeuf
RNA helicases comprise the largest family of enzymes involved in the metabolism of mRNAs, the processing and fate of which rely on their packaging into messenger ribonucleoprotein particles (mRNPs). In this Review, we describe how the capacity of some RNA helicases to either remodel or (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 1, 2016 Category: Cytology Authors: Cyril F. BourgeoisFranck MortreuxDidier Auboeuf Tags: Review Source Type: research
Membrane trafficking: The second job of ULKs
Nature Reviews Molecular Cell Biology 17, 396 (2016).
doi:10.1038/nrm.2016.77
Author: Paulina Strzyz
Autophagy-initiating kinases ULK1 and ULK2 are now shown to function independently of autophagy in regulating protein trafficking from the ER. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - June 1, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Introducing STRaNDs: shuttling transcriptional regulators that are non-DNA binding
Nature Reviews Molecular Cell Biology 17, 523 (2016).
doi:10.1038/nrm.2016.41
Authors: Min Lu, Mary R. Muers & Xin Lu
Many proteins originally identified as cytoplasmic — including many associated with the cytoskeleton or cell junctions — are increasingly being found in the nucleus, where they have specific functions. Here, we focus on proteins that translocate from the cytoplasm to the nucleus in response to (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 24, 2016 Category: Cytology Authors: Min Lu Mary R. Muers Xin Lu Tags: Perspectives Source Type: research
A four-lane highway to cancer
Nature Reviews Molecular Cell Biology 17, 398 (2016).
doi:10.1038/nrm.2016.73
Authors: Lorenzo Galluzzi & Guido Kroemer
Galluzzi and Kroemer take advantage of a large study of somatic copy number alterations to revisit the previously suggested idea that cancer aneuploidy frequently arises from genome duplication. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 24, 2016 Category: Cytology Authors: Lorenzo GalluzziGuido Kroemer Tags: Research Highlight Source Type: research
Chromatin: BRD4 kicks out nucleosomes with its HAT
Nature Reviews Molecular Cell Biology 17, 396 (2016).
doi:10.1038/nrm.2016.72
Author: Paulina Strzyz
Bromodomain protein 4 (BRD4) is shown to possess histone acetyltransferase activity, through which it mediates nucleosome eviction from chromatin, contributing to chromatin decompaction. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 24, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
Nature Reviews Molecular Cell Biology 17, 379 (2016).
doi:10.1038/nrm.2016.58
Authors: Petra Schwertman, Simon Bekker-Jensen & Niels Mailand
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition and faithful repair of such damage is crucial for the maintenance of genomic stability, as well as for cell and organismal fitness. Signalling by ubiquitin, SUMO and other ubiquitin-like modifiers (UBLs) orchestrates and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 22, 2016 Category: Cytology Authors: Petra SchwertmanSimon Bekker-JensenNiels Mailand Tags: Review Source Type: research
The world of DNA in glycol solution
Nature Reviews Molecular Cell Biology 17, 335 (2016).
doi:10.1038/nrm.2016.66
Author: Tomas Lindahl
The properties of high-molecular-weight DNA are usually investigated in neutral aqueous solutions. Strong acids and strong alkaline solutions are obviously unsuitable, as are corrosive solvents, and DNA is insoluble in most organic solvents; precipitation of DNA from aqueous solution with ethanol or isopropanol is therefore (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 22, 2016 Category: Cytology Authors: Tomas Lindahl Tags: Comment Source Type: research
DNA damage response: p53 curbs topological stress
Nature Reviews Molecular Cell Biology 17, 332 (2016).
doi:10.1038/nrm.2016.70
Author: Eytan Zlotorynski
Excessive DNA unwinding in S phase by DNA and RNA polymerases causes topological stress which, if not relieved by topoisomerase II (Topo II), can lead to DNA damage. Investigating why p53-deficient cells are more sensitive to Topo II inhibitors, Yeo et al. showed that (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 22, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Ion transporters: Potassium channel regulates ciliogenesis
Nature Reviews Molecular Cell Biology 17, 332 (2016).
doi:10.1038/nrm.2016.69
Author: Paulina Strzyz
Kv10.1 is a voltage-gated potassium channel, whose upregulation can lead to severe developmental disorders and to cancer. Sánchez et al. found that in mammalian cells, Kv10.1 can localize to primary cilia, where it promotes cilia disassembly — a process that (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 22, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Genome engineering: Presenting Argonaute, the genome editor
Nature Reviews Molecular Cell Biology 17, 332 (2016).
doi:10.1038/nrm.2016.68
Author: Eytan Zlotorynski
Argonaute proteins are endonucleases that typically require 5′-phosphorylated, short single-stranded guide RNAs (gRNA) for targeting and cleavage of transcripts; however, some prokaryotic Argonautes cleave DNA, similarly to the endonuclease Cas9. Unlike Cas9, DNA-cleaving Argonautes use gDNA rather than gRNA and do not require auxiliary sequences (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 22, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Ageing: The yin and yang of mitochondrial dysfunction
Nature Reviews Molecular Cell Biology 17, 331 (2016).
doi:10.1038/nrm.2016.71
Author: Kim Baumann
Three studies provide important insights into mitochondrial function during ageing — they reveal a connection to stem cell senescence and shed light on the epigenetic mechanisms underlying UPRmt activation and stress-induced longevity. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 22, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Stop pulling my strings — what telomeres taught us about the DNA damage response
Nature Reviews Molecular Cell Biology 17, 364 (2016).
doi:10.1038/nrm.2016.43
Authors: Eros Lazzerini-Denchi & Agnel Sfeir
Mammalian cells have evolved specialized mechanisms to sense and repair double-strand breaks (DSBs) to maintain genomic stability. However, in certain cases, the activity of these pathways can lead to aberrant DNA repair, genomic instability and tumorigenesis. One such case is DNA repair at the natural (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 10, 2016 Category: Cytology Authors: Eros Lazzerini-DenchiAgnel Sfeir Tags: Review Source Type: research
Cytoskeleton: Microtubules set the beat
Nature Reviews Molecular Cell Biology 17, 333 (2016).
doi:10.1038/nrm.2016.63
Author: Paulina Strzyz
Microtubule detyrosination is shown to influence mechanical properties of cardiomyocytes, as detyrosinated microtubules resist the force of contraction by undergoing buckling. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 10, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
