Stop pulling my strings — what telomeres taught us about the DNA damage response

Nature Reviews Molecular Cell Biology 17, 364 (2016). doi:10.1038/nrm.2016.43 Authors: Eros Lazzerini-Denchi & Agnel Sfeir Mammalian cells have evolved specialized mechanisms to sense and repair double-strand breaks (DSBs) to maintain genomic stability. However, in certain cases, the activity of these pathways can lead to aberrant DNA repair, genomic instability and tumorigenesis. One such case is DNA repair at the natural
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research