Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

Nature Reviews Molecular Cell Biology 17, 379 (2016). doi:10.1038/nrm.2016.58 Authors: Petra Schwertman, Simon Bekker-Jensen & Niels Mailand DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition and faithful repair of such damage is crucial for the maintenance of genomic stability, as well as for cell and organismal fitness. Signalling by ubiquitin, SUMO and other ubiquitin-like modifiers (UBLs) orchestrates and
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research