Nature Reviews Molecular Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Unfolded protein response: Pro-survival clock sUPRession
Nature Reviews Molecular Cell Biology 19, 74 (2018).
doi:10.1038/nrm.2017.137
Author: Paulina Strzyz
Activation of the unfolded protein response suppresses circadian clock genes, which contributes to translation repression and increased cell survival. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 20, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Ten principles of heterochromatin formation and function
Nature Reviews Molecular Cell Biology 19, 229 (2018).
doi:10.1038/nrm.2017.119
Authors: Robin C. Allshire & Hiten D. Madhani
Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows particular genomic domains with specific functional properties. The capacity of heterochromatin to restrain the activity of mobile elements, isolate DNA repair in repetitive regions and ensure accurate chromosome segregation is crucial for maintaining genomic (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 13, 2017 Category: Cytology Authors: Robin C. Allshire Hiten D. Madhani Tags: Review Source Type: research
Ageing: Pol III inhibition: new promise of longevity
Nature Reviews Molecular Cell Biology 19, 74 (2018).
doi:10.1038/nrm.2017.131
Author: Paulina Strzyz
Inhibition of polymerase III in the gut is shown to promote animal lifespan downstream of the TOR complex 1. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 13, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Transcription regulation by the Mediator complex
Nature Reviews Molecular Cell Biology 19, 262 (2018).
doi:10.1038/nrm.2017.115
Author: Julie Soutourina
Alterations in the regulation of gene expression are frequently associated with developmental diseases or cancer. Transcription activation is a key phenomenon in the regulation of gene expression. In all eukaryotes, mediator of RNA polymerase II transcription (Mediator), a large complex with modular organization, is generally (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 6, 2017 Category: Cytology Authors: Julie Soutourina Tags: Review Source Type: research
Splicing: Going in circles
Nature Reviews Molecular Cell Biology 19, 3 (2018).
doi:10.1038/nrm.2017.128
Author: Eytan Zlotorynski
The production of circular RNAs is enhanced when canonical splicing of parent genes or transcription termination at upstream genes is reduced. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - December 6, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Chromatin dependencies in cancer and inflammation
Nature Reviews Molecular Cell Biology 19, 245 (2018).
doi:10.1038/nrm.2017.113
Authors: Ivan Marazzi, Benjamin D. Greenbaum, Diana H. P. Low & Ernesto Guccione
Multiple cell-signalling pathways converge on chromatin to induce gene expression programmes. The inducible transcriptional programmes that are established as a result of inflammatory or oncogenic signals are controlled by shared chromatin regulators. Therapeutic targeting of such chromatin dependencies has proved effective for controlling tumorigenesis and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 29, 2017 Category: Cytology Authors: Ivan Marazzi Benjamin D. Greenbaum Diana H. P. Low Ernesto Guccione Tags: Review Source Type: research
Stem cells: Regenerating the skin of a young patient
Nature Reviews Molecular Cell Biology 19, 1 (2018).
doi:10.1038/nrm.2017.124
Author: Kim Baumann
The entire skin of a young patient with junctional epidermolysis bullosa was successfuly regenerated using a combination of ex vivo gene therapy and stem-cell replacement therapy, which is a major achievement in the translation of stem cell-based therapies to the clinic. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 29, 2017 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Sphingolipids and their metabolism in physiology and disease
Nature Reviews Molecular Cell Biology 19, 175 (2018).
doi:10.1038/nrm.2017.107
Authors: Yusuf A. Hannun & Lina M. Obeid
Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many functions, which rivals, if not exceeds, that of the genome or proteome. These results highlight critical (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 22, 2017 Category: Cytology Authors: Yusuf A. Hannun Lina M. Obeid Tags: Review Source Type: research
Functional 5 ′ UTR mRNA structures in eukaryotic translation regulation and how to find them
Nature Reviews Molecular Cell Biology 19, 158 (2018).
doi:10.1038/nrm.2017.103
Authors: Kathrin Leppek, Rhiju Das & Maria Barna
RNA molecules can fold into intricate shapes that can provide an additional layer of control of gene expression beyond that of their sequence. In this Review, we discuss the current mechanistic understanding of structures in 5′ untranslated regions (UTRs) of eukaryotic mRNAs and the emerging (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 22, 2017 Category: Cytology Authors: Kathrin Leppek Rhiju Das Maria Barna Tags: Review Source Type: research
The mitochondrial UPR: mechanisms, physiological functions and implications in ageing
Nature Reviews Molecular Cell Biology 19, 109 (2018).
doi:10.1038/nrm.2017.110
Authors: Tomer Shpilka & Cole M. Haynes
Mitochondrial function declines during ageing owing to the accumulation of deleterious mitochondrial genomes and damage resulting from the localized generation of reactive oxygen species, both of which are often exacerbated in diseases such as Parkinson disease. Cells have several mechanisms to assess mitochondrial function and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 22, 2017 Category: Cytology Authors: Tomer Shpilka Cole M. Haynes Tags: Review Source Type: research
Chromosome biology: Spindle asymmetry drives selfish segregation
Nature Reviews Molecular Cell Biology 19, 2 (2018).
doi:10.1038/nrm.2017.121
Author: Paulina Strzyz
Tubulin in meiotic oocyte spindles is asymmetrically tyrosinated, and this spindle asymmetry can drive biased, non-Mendelian inheritance of chromosomes. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 22, 2017 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
RNA metabolism: The short tail that wags the mRNA
Nature Reviews Molecular Cell Biology 19, 2 (2018).
doi:10.1038/nrm.2017.120
Author: Eytan Zlotorynski
In contrast to the prevailing view, abundant and efficiently translated mRNAs tend to have short, pruned poly(A) tails. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 22, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
The functions and unique features of long intergenic non-coding RNA
Nature Reviews Molecular Cell Biology 19, 143 (2018).
doi:10.1038/nrm.2017.104
Authors: Julia D. Ransohoff, Yuning Wei & Paul A. Khavari
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 15, 2017 Category: Cytology Authors: Julia D. Ransohoff Yuning Wei Paul A. Khavari Tags: Review Source Type: research
Publisher correction: The essential kinase ATR: ensuring faithful duplication of a challenging genome.
Nature Reviews Molecular Cell Biology 18, 783 (2017).
doi:10.1038/nrm.2017.116
Author: Joshua C. Saldivar, David Cortez & Karlene A. Cimprich
Nature Reviews Molecular Cell Biology18, 622–636 (2017)In the original article, references 36, 68 and 110 contained mistakes. These have now been corrected in the HTML and PDF versions of the article. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 8, 2017 Category: Cytology Authors: Joshua C. Saldivar David Cortez Karlene A. Cimprich Tags: Correction Source Type: research
Mechanobiology of collective cell behaviours
Nature Reviews Molecular Cell Biology 18, 743 (2017).
doi:10.1038/nrm.2017.98
Authors: Benoit Ladoux & René-Marc Mège
The way in which cells coordinate their behaviours during various biological processes, including morphogenesis, cancer progression and tissue remodelling, largely depends on the mechanical properties of the external environment. In contrast to single cells, collective cell behaviours rely on the cellular interactions not only with (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - November 8, 2017 Category: Cytology Authors: Benoit Ladoux Ren é -Marc M è ge Tags: Review Source Type: research
