Chromatin dependencies in cancer and inflammation

Nature Reviews Molecular Cell Biology 19, 245 (2018). doi:10.1038/nrm.2017.113 Authors: Ivan Marazzi, Benjamin D. Greenbaum, Diana H. P. Low & Ernesto Guccione Multiple cell-signalling pathways converge on chromatin to induce gene expression programmes. The inducible transcriptional programmes that are established as a result of inflammatory or oncogenic signals are controlled by shared chromatin regulators. Therapeutic targeting of such chromatin dependencies has proved effective for controlling tumorigenesis and
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research