Nature Reviews Molecular Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Genome-wide mapping and analysis of chromosome architecture
Nature Reviews Molecular Cell Biology 17, 743 (2016).
doi:10.1038/nrm.2016.104
Authors: Anthony D. Schmitt, Ming Hu & Bing Ren
Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects DNA replication, transcription and the repair of DNA damage. Thus, a thorough understanding of nuclear architecture is fundamental to the study of nuclear processes (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 31, 2016 Category: Cytology Authors: Anthony D. Schmitt Ming Hu Bing Ren Tags: Review Source Type: research
Cancer biology: Hypoxia as an off switch for gene expression
Nature Reviews Molecular Cell Biology 17, 610 (2016).
doi:10.1038/nrm.2016.119
Author: Paulina Strzyz
A new study shows that hypoxia interferes with DNA demethylation, resulting in DNA hypermethylation and repression of gene expression, which in tumours leads to the silencing of tumour suppressors. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 31, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Mechanisms of disease: Intracellular tunnels spread disease
Nature Reviews Molecular Cell Biology 17, 608 (2016).
doi:10.1038/nrm.2016.124
Author: Kirsty Minton
Fibrillar α-synuclein is transferred between neuronal cells within lysosomes in tunelling nanotubes. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 31, 2016 Category: Cytology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Cell migration: Fascin and 3D nuclear moves
Nature Reviews Molecular Cell Biology 17, 608 (2016).
doi:10.1038/nrm.2016.123
Author: Kim Baumann
Fascin promotes cell invasion by functioning as a mechanotransducer that binds to nesprin-2 and couples F-actin to the nuclear envelope. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 31, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
p53: Understanding the actions of 53BP1
Nature Reviews Molecular Cell Biology 17, 608 (2016).
doi:10.1038/nrm.2016.120
Author: Katharine H. Wrighton
A new study shows that 53BP1 modulates p53-mediated transcription independently of its functions in DNA repair. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 31, 2016 Category: Cytology Authors: Katharine H. Wrighton Tags: Research Highlight Source Type: research
Control of brown and beige fat development
Nature Reviews Molecular Cell Biology 17, 691 (2016).
doi:10.1038/nrm.2016.96
Authors: Wenshan Wang & Patrick Seale
Brown and beige adipocytes expend chemical energy to produce heat and are therefore important in regulating body temperature and body weight. Brown adipocytes develop in discrete and relatively homogenous depots of brown adipose tissue, whereas beige adipocytes are induced to develop in white adipose tissue (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 23, 2016 Category: Cytology Authors: Wenshan Wang Patrick Seale Tags: Review Source Type: research
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Nature Reviews Molecular Cell Biology 17, 679 (2016).
doi:10.1038/nrm.2016.93
Authors: Michael S. Bonkowski & David A. Sinclair
The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 23, 2016 Category: Cytology Authors: Michael S. Bonkowski David A. Sinclair Tags: Review Source Type: research
Post-translational modifications: Extension of the tubulin code
Nature Reviews Molecular Cell Biology 17, 609 (2016).
doi:10.1038/nrm.2016.117
Author: Paulina Strzyz
The histone methyltransferase SETD2 methylates microtubules during mitosis, thereby preventing mitotic errors and genomic instability. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 23, 2016 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research
Coenzyme A: to make it or uptake it?
Nature Reviews Molecular Cell Biology 17, 605 (2016).
doi:10.1038/nrm.2016.110
Authors: Ody C.M. Sibon & Erick Strauss
The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 23, 2016 Category: Cytology Authors: Ody C.M. Sibon Erick Strauss Tags: Comment Source Type: research
Nuclear organization: Keeping X chromosomes quiet
Nature Reviews Molecular Cell Biology 17, 534 (2016).
doi:10.1038/nrm.2016.112
Author: Katharine H. Wrighton
A Xist–lamin B receptor interaction recruits the X chromosome to the nuclear lamina to enable Xist-mediated gene silencing. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 21, 2016 Category: Cytology Authors: Katharine H. Wrighton Tags: Research Highlight Source Type: research
Nuclear organization: The plant nucleolus arranges chromosomes
Nature Reviews Molecular Cell Biology 17, 534 (2016).
doi:10.1038/nrm.2016.115
Author: Kim Baumann
The nucleolus — the site of rRNA gene transcription and ribosome biogenesis — is the largest nuclear body. Pontvianne et al. identified nucleolus-associated chromatin domains (NADs) in plants. Nucleoli were purified from Arabidopsis thaliana leaves and DNA sequencing revealed that, in addition to (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 21, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
Protein metabolism: Ceramide switches membrane protein topology
Nature Reviews Molecular Cell Biology 17, 534 (2016).
doi:10.1038/nrm.2016.114
Author: Kim Baumann
Chen et al. report that the lipid ceramide inverts the membrane orientation of the endoplasmic reticulum (ER) transmembrane protein TM4SF20, thereby changing its function. Without ceramide, the amino terminus of TM4SF20 was exposed to the ER lumen, and insertion in this orientation required the (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 21, 2016 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research
RNA decay: The exosome TRAMPs on viral RNA
Nature Reviews Molecular Cell Biology 17, 534 (2016).
doi:10.1038/nrm.2016.113
Author: Eytan Zlotorynski
Performing RNAi screens for factors that restrict several RNA viruses in fruit flies, Molleston et al. discovered that depletion of the 3′ to 5′ exonucleases dRrp6 or dDis3, which are the catalytic subunits of the RNA exosome complex, or depletion of dMtr4 or dZcchc7, (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 21, 2016 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Subversion of host genome integrity by bacterial pathogens
Nature Reviews Molecular Cell Biology 17, 659 (2016).
doi:10.1038/nrm.2016.100
Authors: Cindrilla Chumduri, Rajendra Kumar Gurumurthy, Rike Zietlow & Thomas F. Meyer
Mammalian cells possess sophisticated genome surveillance and repair mechanisms, executed by the so-called DNA damage response (DDR), failure of which leads to accumulation of DNA damage and genomic instability. Mounting evidence suggests that bacterial infections can elicit DNA damage in host cells, and certain pathogens (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 17, 2016 Category: Cytology Authors: Cindrilla Chumduri Rajendra Kumar Gurumurthy Rike Zietlow Thomas F. Meyer Tags: Review Source Type: research
Notch signalling in context
Nature Reviews Molecular Cell Biology 17, 722 (2016).
doi:10.1038/nrm.2016.94
Author: Sarah J. Bray
The highly conserved Notch signalling pathway functions in many different developmental and homeostatic processes, which raises the question of how this pathway can achieve such diverse outcomes. With a direct route from the membrane to the nucleus, the Notch pathway has fewer opportunities for regulation (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - August 9, 2016 Category: Cytology Authors: Sarah J. Bray Tags: Review Source Type: research
