Protein metabolism: Ceramide switches membrane protein topology

Nature Reviews Molecular Cell Biology 17, 534 (2016). doi:10.1038/nrm.2016.114 Author: Kim Baumann Chen et al. report that the lipid ceramide inverts the membrane orientation of the endoplasmic reticulum (ER) transmembrane protein TM4SF20, thereby changing its function. Without ceramide, the amino terminus of TM4SF20 was exposed to the ER lumen, and insertion in this orientation required the
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Research Highlight Source Type: research