Protein metabolism: Ceramide switches membrane protein topology
Nature Reviews Molecular Cell Biology 17, 534 (2016).
doi:10.1038/nrm.2016.114
Author: Kim Baumann
Chen et al. report that the lipid ceramide inverts the membrane orientation of the endoplasmic reticulum (ER) transmembrane protein TM4SF20, thereby changing its function. Without ceramide, the amino terminus of TM4SF20 was exposed to the ER lumen, and insertion in this orientation required the
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research