Subversion of host genome integrity by bacterial pathogens

Nature Reviews Molecular Cell Biology 17, 659 (2016). doi:10.1038/nrm.2016.100 Authors: Cindrilla Chumduri, Rajendra Kumar Gurumurthy, Rike Zietlow & Thomas F. Meyer Mammalian cells possess sophisticated genome surveillance and repair mechanisms, executed by the so-called DNA damage response (DDR), failure of which leads to accumulation of DNA damage and genomic instability. Mounting evidence suggests that bacterial infections can elicit DNA damage in host cells, and certain pathogens
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research