The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Nature Reviews Molecular Cell Biology 19, 109 (2018). doi:10.1038/nrm.2017.110 Authors: Tomer Shpilka & Cole M. Haynes Mitochondrial function declines during ageing owing to the accumulation of deleterious mitochondrial genomes and damage resulting from the localized generation of reactive oxygen species, both of which are often exacerbated in diseases such as Parkinson disease. Cells have several mechanisms to assess mitochondrial function and
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research