DNA damage response: p53 curbs topological stress

Nature Reviews Molecular Cell Biology 17, 332 (2016). doi:10.1038/nrm.2016.70 Author: Eytan Zlotorynski Excessive DNA unwinding in S phase by DNA and RNA polymerases causes topological stress which, if not relieved by topoisomerase II (Topo II), can lead to DNA damage. Investigating why p53-deficient cells are more sensitive to Topo II inhibitors, Yeo et al. showed that
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Research Highlight Source Type: research