Structural insights into the catalysis and regulation of E3 ubiquitin ligases

Nature Reviews Molecular Cell Biology 17, 626 (2016). doi:10.1038/nrm.2016.91 Authors: Lori Buetow & Danny T. Huang Covalent attachment (conjugation) of one or more ubiquitin molecules to protein substrates governs numerous eukaryotic cellular processes, including apoptosis, cell division and immune responses. Ubiquitylation was originally associated with protein degradation, but it is now clear that ubiquitylation also mediates processes such as protein–protein interactions
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research