The HSP90 chaperone machinery

Nature Reviews Molecular Cell Biology 18, 345 (2017). doi:10.1038/nrm.2017.20 Authors: Florian H. Schopf, Maximilian M. Biebl & Johannes Buchner The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells. As HSP90 has several hundred protein substrates (or 'clients'), it is involved in many cellular processes beyond protein folding, which include DNA
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research