Gene expression: ACSS2 boosts local histone acetylation

Nature Reviews Molecular Cell Biology 18, 405 (2017).
doi:10.1038/nrm.2017.61

Author: Eytan Zlotorynski
During metabolic stress in cancer cells, ACSS2 binds to TFEB to locally boost the production of acetyl-CoA, thereby facilitating the expression of lysosomal and autophagy genes.

Source: Nature Reviews Molecular Cell Biology - June 7, 2017 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research