Mechanisms of DNA – protein crosslink repair

Nature Reviews Molecular Cell Biology 18, 563 (2017).
doi:10.1038/nrm.2017.56

Authors: Julian Stingele, Roberto Bellelli & Simon J. Boulton
Covalent DNA–protein crosslinks (DPCs, also known as protein adducts) of topoisomerases and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that induce DPCs include widely used classes of chemotherapeutics. Their bulkiness blocks virtually every chromatin-based process and makes them intractable

Source: Nature Reviews Molecular Cell Biology - June 28, 2017 Category: Cytology Authors: Julian Stingele Roberto Bellelli Simon J. Boulton Tags: Review Source Type: research