Cancer biology: Therapy-induced transcription is cryptically widespread

Nature Reviews Molecular Cell Biology 18, 469 (2017). doi:10.1038/nrm.2017.64 Author: Darren J. Burgess Inhibitors of DNA methyltransferases and of histone deacetylases induce transcription from cryptic transposable elements, which results in 5′-truncated and mis-spliced proteins that may increase cancer immunogenicity.

http://dx.doi.org/10.1038/nrm.2017.64

Source: Nature Reviews Molecular Cell Biology - June 28, 2017 Category: Cytology Authors: Darren J. Burgess Tags: Research Highlight Source Type: research

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