Histone variants on the move: substrates for chromatin dynamics

Nature Reviews Molecular Cell Biology 18, 115 (2017). doi:10.1038/nrm.2016.148 Authors: Paul B. Talbert & Steven Henikoff Most histones are assembled into nucleosomes behind the replication fork to package newly synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are typically incorporated throughout the cell cycle. Histone variants can profoundly change chromatin properties, which in turn affect DNA replication
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research