Mechanisms of disease: Metabolic reprogramming cures liver disease
Nature Reviews Molecular Cell Biology 17, 610 (2016).
doi:10.1038/nrm.2016.129
Author: Eytan Zlotorynski
Hereditary tyrosinaemia type I (HT-I) is a lethal liver disease that is caused by mutations in FAH, which encodes fumarylacetoacetate hydrolase, the enzyme that catalyses the final step of tyrosine catabolism. FAH deficiency leads to the accumulation of toxic metabolic intermediates that cause hepatocellular
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
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