Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

Nature Reviews Molecular Cell Biology 17, 703 (2016).
doi:10.1038/nrm.2016.111

Authors: Yves Pommier, Yilun Sun, Shar-yin N. Huang & John L. Nitiss
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove catenanes and enable chromosome segregation. Human cells encode six topoisomerases (TOP1, TOP1mt, TOP2α, TOP2β, TOP3α and TOP3β), which act on a broad range of DNA and RNA substrates at the nuclear and mitochondrial genomes. Their

Source: Nature Reviews Molecular Cell Biology - September 20, 2016 Category: Cytology Authors: Yves Pommier Yilun Sun Shar-yin N. Huang John L. Nitiss Tags: Review Source Type: research