DNA Repair: RNA –DNA hybrids: a double-edged sword in genomic stability

Nature Reviews Molecular Cell Biology 17, 740 (2016). doi:10.1038/nrm.2016.155 Author: Paulina Strzyz The formation of RNA–DNA hybrids results in replicative stress and, as a consequence, the emergence of DNA double-strand breaks (DSBs). Thus, RNA–DNA hybrid formation has been primarily associated with genomic instability. The findings of Ohle et al. now change this view, implicating RNA–DNA hybrids
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Research Highlight Source Type: research