Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

Nature Reviews Molecular Cell Biology 18, 246 (2017). doi:10.1038/nrm.2016.143 Authors: Takao Fujisawa & Panagis Filippakopoulos Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research