Glucocorticoid receptor control of transcription: precision and plasticity via allostery

Nature Reviews Molecular Cell Biology 18, 159 (2017). doi:10.1038/nrm.2016.152 Authors: Emily R. Weikum, Matthew T. Knuesel, Eric A. Ortlund & Keith R. Yamamoto The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular and physiological contexts. The precision of GR-mediated responses seems to depend on combinatorial, context-specific assembly of GR-nucleated transcription regulatory complexes at
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research